a disorder which causes fibrosis of the bone marrow
Medical technology saved his life when he was first diagnosed with myelofibrosis
myelofibrosis in American English
(ˌmaiəloufaiˈbrousɪs)
noun
Pathology
the replacement of bone marrow by fibrous tissue, characteristic of leukemia and certain other diseases
Word origin
[1945–50; myelo- + fibrosis]
Examples of 'myelofibrosis' in a sentence
myelofibrosis
This supports the hypothesis of idiopathic myelofibrosis-associated seronegative polyarthritis.
Xavier Guillot, Marius Moldovan, Claire Vidon, Daniel Wendling 2014, 'Myelofibrosis-Related Arthritis Successfully Treated with Hydroxyurea', Case Reports in Rheumatologyhttp://dx.doi.org/10.1155/2014/869743. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Four patients had primary myelofibrosis, and one had chronic anemia.
I-Shiow Jan, Ming-Hsiang Weng, Chih-Yuan Wang, Tien-Chun Chang, Shyang-Rong Shih 2018, 'Extramedullary hematopoiesis involving the thyroid: A rare cytologic finding in otherwisehealthy patients and review of literature', Journal of the Formosan Medical Associationhttp://www.sciencedirect.com/science/article/pii/S0929664617306745. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Differential diagnosis with primary myelofibrosis may be difficult and hybrid cases may occur.
Romeo Maura, Chauffaille Maria de Lourdes Lopes Ferrari, Bahia Daniella Marcia Maranhão,Silva Maria Regina Regis 2002, 'Hyperfibrotic myelodysplasia: case report with response to steroid therapy', Jornal Brasileiro de Patologia e Medicina Laboratorialhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442002000200012. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In our four-year observation period, transitions to primary myelofibrosis and acute leukemia were considerably low.
Karla Rener, Samo Zver 2012, 'Characteristics and treatment of patients with essential thrombocythemia during theperiod of 2008–2011', Zdravniški Vestnikhttp://vestnik.szd.si/index.php/ZdravVest/article/view/745. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Myelofibrosis and gallbladder carcinoma are both very rare diseases.
Sophie A. Gray, Menno H. Raber, Esther Provoost, Gert-Jan Toes, Joost M. Klaase 2015, 'Colorectal Liver Metastasis, Primary Gallbladder Carcinoma and Myelofibrosis PresentSimultaneously in a Liver Resection Specimen', Case Reports in Gastroenterologyhttp://www.karger.com/Article/FullText/441383. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Urticarial vasculitis may accompany various systemic disorders, including primary myelofibrosis.
Radomir Reszke, Adam Reich 2017, 'Urticarial vasculitis coexisting with primary myelofibrosis – a case report', Przegląd Dermatologicznyhttps://www.termedia.pl/Urticarial-vasculitis-coexisting-with-primary-myelofibrosis-a-case-report,56,31177,1,1.html. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
One of them had associated polycythaemia vera, myelofibrosis, mucosal lesions and haemorrhagic blisters.
Mohan Singh, S Verma, S Kaur, Bishan D Radotra 1986, 'Acute Febrile Neutrophilic Dermatosis (sweet′s Syndrome)', Indian Journal of Dermatology, Venereology and Leprologyhttp://www.ijdvl.com/article.asp?issn=0378-6323;year=1986;volume=52;issue=3;spage=170;epage=173;aulast=Singh;type=0. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
No deaths were recorded and one transformation to myelofibrosis was seen during follow-up.
Graeme Greenfield, Mary Frances McMullin 2018, 'Splanchnic venous thrombosis in JAK2 V617F mutation positive myeloproliferative neoplasms– long term follow-up of a regional case series', Thrombosis Journalhttp://link.springer.com/article/10.1186/s12959-018-0187-z. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
In addition, primary hyperparathyroidism can be associated with anemia and myelofibrosis.
Shu-Chuan Huang, Vin-Cent Wu, Guan Chou, Tzu-Yu Huang, Shih-Yi Lin, Wayne Huey-HerngSheu 2007, 'Benign Parathyroid Adenoma Presenting with Unusual Parathyroid Crisis, Anemia andMyelofibrosis', Journal of the Formosan Medical Associationhttp://www.sciencedirect.com/science/article/pii/S0929664609603466. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Accordingly, this gene-signature may reflect key processes in the pathogenesis and pathophysiology of myelofibrosis development.
Hans Carl Hasselbalch, Vibe Skov, Thomas Stauffer Larsen, Mads Thomassen, CarolineHasselbalch Riley, Morten K Jensen, Ole Weis Bjerrum, Torben A Kruse 2014, 'Transcriptional profiling of whole blood identifies a unique 5-gene signature formyelofibrosis and imminent myelofibrosis transformation.', PLoS ONEhttp://europepmc.org/articles/PMC3890316?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)