of, relating to or resembling muscarine or its physiological action
2.
(of a receptor) able to respond to muscarine
The binding of acetylcholine to muscarinic receptors illustrates the phenomenon ofslow inhibitory transmission.
muscarinic in American English
(ˌmʌskəˈrɪnɪk)
adjective
1.
of or pertaining to muscarine
2.
related to or imitating the action of muscarine on neurons, esp. in blocking cholinergic effects
Word origin
[muscarine + -ic]
Examples of 'muscarinic' in a sentence
muscarinic
A concomitant long-acting muscarinic antagonist will be allowed at stable doses.
Calverley PM, Martinez FJ, Fabbri LM, Goehring UM, Rabe KF 2012, 'Does roflumilast decrease exacerbations in severe COPD patients not controlled byinhaled combination therapy? the REACT study protocol', International Journal of COPDhttp://www.dovepress.com/does-roflumilast-decrease-exacerbations-in-severe-copd-patients-not-co-a10163. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Acetylcholine receptors are of two main types, nicotinic and muscarinic.
Crittenden Elizabeth L, González Alfredo, García Dana M 2004, 'Activation of muscarinic acetylcholine receptors elicits pigment granule dispersionin retinal pigment epithelium isolated from bluegill', BMC Neurosciencehttp://www.biomedcentral.com/1471-2202/5/23. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The specific muscarinic agonist oxotremorine and arecoline failed to elicit contractions.
Tibor Kiss, Nóra Krajcs, Zsolt Pirger, László Hernádi 2014, 'Nicotinic acetylcholine receptors containing the α7-like subunit mediate contractionsof muscles responsible for space positioning of the snail, Helix pomatia L. tentacle.',PLoS ONEhttp://europepmc.org/articles/PMC4193815?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Specifically, muscarinic and histaminergic pathways seem to play important roles.
Ana Maria Volpato, Alexandra Ioppi Zugno, João Quevedo 2013, 'Recent evidence and potential mechanisms underlying weight gain and insulin resistancedue to atypical antipsychotics', Revista Brasileira de Psiquiatriahttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462013000300295&lng=en&tlng=en. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Most notably epithelial cells and inflammatory cells generate acetylcholine, and express functional muscarinic receptors.
Zaagsma Johan, Gosens Reinoud, Meurs Herman, Halayko Andrew J 2006, 'Muscarinic receptor signaling in the pathophysiology of asthma and COPD', Respiratory Researchhttp://respiratory-research.com/content/7/1/73. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
These patients can initially be managed with hyoscyamine, a muscarinic antagonist.
Mohammad Saud Khan, Abhinav Tiwari, Zubair Khan, Himani Sharma, Mohammad Taleb, JeffreyHammersley 2017, 'Pyridostigmine Induced Prolonged Asystole in a Patient with Myasthenia Gravis SuccessfullyTreated with Hyoscyamine', Case Reports in Cardiologyhttp://dx.doi.org/10.1155/2017/6956298. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)