relating to self-stimulation, through the production of a factor and a specific receptor for it
Examples of 'autocrine' in a sentence
autocrine
First, the osteoclast and osteoblast activities were coupled by their autocrine and paracrine effects.
Lingze Liu, Quan Shi, Qiang Chen, Zhiyong Li 2019, 'Mathematical modeling of bone in-growth into undegradable porous periodic scaffoldsunder mechanical stimulus', Journal of Tissue Engineeringhttps://doi.org/10.1177/2041731419827167. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Chemokines are crucial autocrine and paracrine players in tumor development.
Roberto eWurth, Adriana eBajetto, Jeffrey K. Harrison, Federica eBarbieri, TullioeFlorio 2014, 'CXCL12 MODULATION OF CXCR4 AND CXCR7 ACTIVITY IN HUMAN GLIOBLASTOMA STEM-LIKE CELLSAND REGULATION OF THE TUMOR MICROENVIRONMENT', Frontiers in Cellular Neurosciencehttp://journal.frontiersin.org/Journal/10.3389/fncel.2014.00144/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
The membrane permeability of such molecules has potential importance for autocrine like or paracrine-like delivery.
Virginijus eValiunas 2013, 'Cyclic nucleotide permeability through unopposed connexin hemichannels', Frontiers in Pharmacologyhttp://journal.frontiersin.org/Journal/10.3389/fphar.2013.00075/full. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Some of these mediators act in a paracrine fashion while some act in autocrine.
Ayse Balat 2010, 'Kidney is in Trouble with Mediators', Bosnian Journal of Basic Medical Scienceshttps://www.bjbms.org/ojs/index.php/bjbms/article/view/2643. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
This autocrine loop could be of major importance to define new targeted therapies.
Hussein Akil, Aurélie Perraud, Carole Mélin, Marie-Odile Jauberteau, Muriel Mathonnet 2011, 'Fine-tuning roles of endogenous brain-derived neurotrophic factor, TrkB and sortilinin colorectal cancer cell survival.', PLoS ONEhttp://europepmc.org/articles/PMC3180371?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Following expression and activation, yeast cells trap autocrine peptides onto their cell walls.
Jun Ishii, Nobuo Yoshimoto, Kenji Tatematsu, Shun'ichi Kuroda, Chiaki Ogino, HidekiFukuda, Akihiko Kondo 2012, 'Cell wall trapping of autocrine peptides for human G-protein-coupled receptors onthe yeast cell surface.', PLoS ONEhttp://europepmc.org/articles/PMC3356411?pdf=render. Retrieved from PLOS CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
It can increase function and number of neutrophils in an autocrine manner.
Xiao-Feng Lai, Hua-Di Qin, Lei-Lei Guo, Zi-Guo Luo, Jing Chang, Chun-Chang Qin 2014, 'Hypercholesterolemia Increases the Production of Leukotriene B4 in Neutrophils byEnhancing the Nuclear Localization of 5-Lipoxygenase', Cellular Physiology and Biochemistryhttp://www.karger.com/Article/FullText/366373. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)
Endothelins are potent predominantly vasoconstricting agents that act as local autocrine and paracrine mediators.
Jiří Patočka, Vladimír Měrka, Vratislav Hrdina, Radomír Hrdina 2005, 'Pharmacological Potential of Endothelin Receptors Agonists and Antagonists', Acta Medicahttps://actamedica.lfhk.cuni.cz/48/2/0067/. Retrieved from DOAJ CC BY 4.0 (https://creativecommons.org/licenses/by-sa/4.0/legalcode)