单词	refractory
释义	refractoryre‧frac‧to‧ry /rɪˈfræktəri/ adjective Word Origin WORD ORIGINrefractory Origin: 1600-1700 Latin refractarius, from refragari ‘to oppose’ Examples EXAMPLES FROM THE CORPUS Initial therapy of patients with large tumor masses has been complicated by large releases of intracellular potassium with resultant refractory hyperkalemia. Monamine oxidase inhibitors are used occasionally in migraine patients who are refractory to other prophylactic drugs. The tale of Gormenghast requires a large number of refractory animals, few of them capable of taking direction. 1formal deliberately not obeying someone in authority and being difficult to deal with or control SYN  unruly2medical a refractory disease or illness is hard to treat or cure
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