transitive. To render foolish or doltish; to stupefy, to besot. Obsolete.

transitive. To confuse, perplex, bewilder; to exhaust, overcome, stupefy; (occasionally) to pester (cf. mither, v. 2). Chiefly reflexive or in passive…

transitive. To make a dunce of; esp. to render (a person) stupid, slow-witted, or confused.

transitive. To besot, render dull or stupid.

To make mentally or morally stupid or blind; to stupefy in mind.

figurative. To make gross (the mind, etc.); to dull, stupefy. Obsolete.

transitive. To make (a person or thing) become cretinous; to cause (something) to become cretinous in character.