carbostyriln.
/ˌkɑːbə(ʊ)ˈstʌɪrɪl/, U.S. /ˌkɑrbəˈstaɪrɪl/ Chemistry.
A crystalline compound produced by the oxidation of quinoline; any of the substituted derivatives of this compound, some of which have pharmacological activity.Carbostyril is a bicyclic lactim, systematic name 2-hydroxyquinoline. Formula: C9H7NO.
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1852 tr. L. Chiozza in Chem. Gaz. 15 June 225 Nitrocinnamic acid being C9H7NO4, the new substance, which may be called carbostyrile, would be formed by the simple deoxidation of the nitrated acid.
1859 H. Watts tr. L. Gmelin Hand-bk. Chem. XIII. 303 Caustic potash readily dissolves carbostyril.
1922 J. J. Sudborough Bernthsen's Text-bk. Org. Chem. (new ed.) xxvi. 482 On reduction the former yields o-amino-cinnamic acid, which readily yields its lactim carbostyril (α-hydroxy-quinoline).
1970 Jrnl. Org. Chem. 35 1757/1 The cyclobutane derivatives of carbostyrils are readily synthesized photochemically without the aid of sensitizers.
2007 Analyt. Sci. 23 x145 Carbostyrils represent a group of naturally occurring lactams, whose potentials as anti-microbial, analgesic, anti-inflammatory, anti-cancer, and anti-HIV agents have recently been reviewed.
This is a new entry (OED Third Edition, December 2008; most recently modified version published online December 2021).
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