transitive. To deprive (a person) of happiness or consolation; to distress, grieve, sadden; to make disconsolate or sorrowful. Also occasionally in…

transitive. To render miserable.

To make joyless and comfortless; to overwhelm with grief; to render wretched.

transitive. To make disconsolate; to dishearten, distress. Also reflexive.

To cause pain, suffering, agony, or anxiety to; to afflict, vex, make miserable. Now chiefly reflexive or passive: cf. distressed, adj.

transitive. To make unhappy or unfortunate.

(un-, prefix2 affix 1a.)

transitive. To make unhappy.