transitive. To deprive of quietness, peace, or rest, bodily or mental; to trouble, disturb, alarm; to make uneasy or restless.

transitive. To destroy or disturb the composure of (a person, the mind, emotions, etc.); to perturb, agitate, unsettle. Also reflexive.

transitive. To irritate, worry, bother; to harass; to tease. English regional (southern) in later use. Now rare.

transitive. To make (mentally or physically) uncomfortable or uneasy; to disconcert. Cf. discomfit, v. 2.