In such a way that no recovery, reparation, or cure is possible; irretrievably; unrectifiably; incurably.

without a chance of reprieve.

So as not to admit of being called or brought back; beyond recall or recovery.

Without the possibility of being reclaimed.

In an irretrievable manner; so as to be irretrievable; beyond recovery or repair; irreparably.

In an irredeemable manner; to an irredeemable extent; so as to be past redemption; hopelessly, absolutely, utterly.