Beyond hope of recovery, help, etc.; in a very advanced stage of some (bad or worsening) state or condition. In predicative use. Also with in, with.

Unwell, in ill health.

In a state of decay; rotting. Obsolete.

In danger, as from illness; dangerously ill. Now dialect and U.S. colloquial.

Affected with or of the nature of (a) canker; infected, ulcerated; gangrenous. Now historical.

Full of sorrow, in despair, utterly dejected. Also: †on the point of death or extinction (obsolete). Cf. amort, adj. Now archaic and rare.

Colloquial phr. (to be) on the danger list: (to be) dangerously ill (as of a patient in hospital).