Grievous, grave; troublesome, oppressive; (of armour) ? formidable.

Pressing heavily upon a person (or persons), burdensome, oppressive. In later use only of public burdens or grievances. Obsolete.

Tormenting, harassing. Obsolete.

That constitutes a nuisance or inconvenience; persistently troublesome; annoying, irritating, irksome. Frequently (esp. in later use) applied to…

Importunate.

Annoying, irritating.

Tending to infest; troublesome, annoying.

= infestious, adj.

Now archaic and rare. That affects like a plague; that causes severe affliction, damage, or distress, or is seen as a punishment or judgement. Obs…

Hostile, inimical, troublesome.

Troublesome, burdensome; importunate.

Besieging; besetting, obsessional.

Of an era, life, etc.: full of trouble or uneasiness.

That pesters; annoying, troublesome.

Of disease: that assails or surrounds.

Haunting, besieging.