In a bitter manner; with bitterness. (See the senses of bitter, adj.)

Of sickness or other physical suffering: Severely, dangerously, seriously.

With difficulty on account of discomfort; only with pain or suffering. Obsolete.

Painfully.

In a way that causes or is accompanied by mental or physical pain; distressingly.

In a dolorous manner; painfully, sorrowfully, dolefully.

Roughly, harshly, severely, painfully.

With reference to a punishment, reproof, etc.: so as to be keenly felt. Obsolete.

In an afflictive manner; so as to distress; painfully, grievously, troublesomely.