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α-ketoglutaric acid
α-ketoglutaric acid n.
Brit. 
/alfəˌkiːtə(ʊ)ɡluːˌtarɪk ˈasɪd/
, /alfəˌkiːtə(ʊ)ɡluːˌtarɪk ˈasɪd/U.S. /ˌælfəˌkidoʊɡluˌtɛrɪk ˈæsəd/
a dibasic keto-acid, HOOC·CO·CH2·CH2·COOH, which is formed by oxidation and decarboxylation of isocitric acid in the Krebs cycle./ˌælfəˌkidoʊɡluˌtɛrɪk ˈæsəd/ΚΠ
1908 Jrnl. Chem. Soc. 94 i. 713 When ethyl oxalosuccinate is treated with hydrogen chloride in the cold and the solution boiled, hydrolysis takes place and α-ketoglutaric acid..is formed.
1937 Biochem. Jrnl. 31 300 α-Ketoglutaric acid thus appears to arise in the course of pyruvic acid oxidation.
1938 Biochem. Jrnl. 32 112 Ten human urines contained between 10 and 40 mg. α-ketoglutaric acid per 24 hr. specimen.
1968 R. F. Steiner Life Chem. xii. 219 α-Ketoglutaric acid represents an important junction between the metabolic pathways of carbohydrates and amino acids.
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