busulfann.

Brit.

/bjuːˈsʌlfan/, U.S.

/bjuˈsəlˌfæn/

Forms: 1900s– busulfan, 1900s– busulphan.

Origin: Formed within English, by derivation. Etymons: butane n., sulphonyl n., sulphonate n., -an suffix.

Etymology: < bu- (in butane n.) + sulf- (in sulphonyl n. or sulphonate n.), elements of the chemical name + -an suffix (compare also -ane suffix²).

Pharmacology.

A drug which is an alkylating agent with a destructive effect on bone marrow, used esp. in the treatment of chronic myeloid leukaemia and in the preparation of patients for bone marrow transplantation.Chemical name: 1,4-di(methanesulphonyloxy)butane; C₆H₁₄O₆S₂.Busulfan is the International Nonproprietary Name (1996). Busulphan is the British Approved Name (1997). A proprietary name for this drug is Myleran n.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia

amethopterin1948

Myleran1952

Laetrile1953

thioguanine1953

thioTEPA1953

mercaptopurine1954

methotrexate1955

busulfan1956

chlorambucil1956

cyclophosphamide1960

vinblastine1962

vincristine1962

levamisole1969

vinca alkaloid1970

doxorubicin1971

tamoxifen1972

Airol1974

trastuzumab1997

thiotepa-

1956 Brit. Med. Jrnl. Feb. 454/1 (table of approved names) Busulphan.

1960 New Scientist 17 Mar. 637/2 There is no cure for leukaemia. There are only palliative drugs such as the corticosteroids..and tumour-inhibiting drugs such as busulphan.

1999 Houston Chron. (Nexis) 13 June a1 As the marrow-killing drugs busulfan and Cytoxan dripped into his veins, the high-school Spanish teacher..thought about the moment his life turned upside down.

2000 L. R. Schover & A. J. Thomas Overcoming Male Infertility xiv. 122 The chemotherapy drugs most damaging to the sperm-producing cells in the testicles are called alkylating drugs. They include cyclophosphamide, chlorambucil, busulfan, procarbazine, [etc.].

This is a new entry (OED Third Edition, March 2012; most recently modified version published online December 2021).

单词	busulfan
释义	busulfann. Brit. /bjuːˈsʌlfan/, U.S. /bjuˈsəlˌfæn/ Forms: 1900s– busulfan, 1900s– busulphan. Origin: Formed within English, by derivation. Etymons: butane n., sulphonyl n., sulphonate n., -an suffix. Etymology: < bu- (in butane n.) + sulf- (in sulphonyl n. or sulphonate n.), elements of the chemical name + -an suffix (compare also -ane suffix²). Pharmacology. A drug which is an alkylating agent with a destructive effect on bone marrow, used esp. in the treatment of chronic myeloid leukaemia and in the preparation of patients for bone marrow transplantation.Chemical name: 1,4-di(methanesulphonyloxy)butane; C₆H₁₄O₆S₂.Busulfan is the International Nonproprietary Name (1996). Busulphan is the British Approved Name (1997). A proprietary name for this drug is Myleran n. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia amethopterin1948 Myleran1952 Laetrile1953 thioguanine1953 thioTEPA1953 mercaptopurine1954 methotrexate1955 busulfan1956 chlorambucil1956 cyclophosphamide1960 vinblastine1962 vincristine1962 levamisole1969 vinca alkaloid1970 doxorubicin1971 tamoxifen1972 Airol1974 trastuzumab1997 thiotepa- 1956 Brit. Med. Jrnl. Feb. 454/1 (table of approved names) Busulphan. 1960 New Scientist 17 Mar. 637/2 There is no cure for leukaemia. There are only palliative drugs such as the corticosteroids..and tumour-inhibiting drugs such as busulphan. 1999 Houston Chron. (Nexis) 13 June a1 As the marrow-killing drugs busulfan and Cytoxan dripped into his veins, the high-school Spanish teacher..thought about the moment his life turned upside down. 2000 L. R. Schover & A. J. Thomas Overcoming Male Infertility xiv. 122 The chemotherapy drugs most damaging to the sperm-producing cells in the testicles are called alkylating drugs. They include cyclophosphamide, chlorambucil, busulfan, procarbazine, [etc.]. This is a new entry (OED Third Edition, March 2012; most recently modified version published online December 2021). < n.1956
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