vinblastinen.
/vɪnˈblastiːn/ Pharmacology.
A cytotoxic alkaloid, C46H58N4O9, obtained from the periwinkle Catharanthus roseus and administered intravenously (usually as the sulphate) in the treatment of lymphomas and other cancers. Cf. vincristine n.
ΘΚΠ
the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia
amethopterin1948
Myleran1952
Laetrile1953
thioguanine1953
thioTEPA1953
mercaptopurine1954
methotrexate1955
busulfan1956
chlorambucil1956
cyclophosphamide1960
vinblastine1962
vincristine1962
levamisole1969
vinca alkaloid1970
doxorubicin1971
tamoxifen1972
Airol1974
trastuzumab1997
thiotepa-
1962 M. R. Karon et al. in Pediatrics XXX. 791/1 Several alkaloids were subsequently isolated from the crude extract [of Vinca rosea], two of which, leurosine and vinblastine (formerly called vincaleukoblastine), markedly inhibited this tumour.
1974 Nature 15 Mar. 239/1 The alkaloids colchicine and vinblastine interfere with the assembly of microtubules, yet they also affect several properties of the surface membrane of animal cells.
1983 D. J. Weatherall et al. Oxf. Textbk. Med. II. xix. 96/1 Vincristine..is preferable to vinblastine..in the treatment of leukaemia.
This entry has not yet been fully updated (first published 1986; most recently modified version published online March 2021).
<
n.1962