triprolidinen.
/trʌɪˈprɒlɪdiːn/ Pharmacology.
A pyrrolidine derivative and histamine H1 antagonist, C19H22N2, given (usually in tablet form as the hydrochloride) to relieve allergic symptoms.
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pyribenzamine1946
diphenhydramine1947
tripelennamine1947
mepyramine1949
anti-histaminic1950
meclozine1955
triprolidine1956
antihistamine1957
trimeprazine1959
methapyrilene1974
1956 Nature 17 Mar. 523/1 The series of spasmolytics, antihistamines and analgesics which we have previously studied, for example, tricyclamol, procyclidine, triprolidine and the thiambutenes.
1966 Jrnl. Pharmacol. & Exper. Therapeutics 152 461/2 Triprolidine and bretylium failed to alter the inotropic action of tyramine significantly.
1977 Gut 18 91 UK-9040, a derivative of the antihistamine triprolidine, is a potent gastric secretory inhibitor.
1990 Jrnl. Clin. Pharmacol. 30 572/1 Triprolidine..is a potent H1-histamine receptor antagonist with proven efficacy in treating symptoms associated with a variety of allergic conditions.
This entry has not yet been fully updated (first published 1993; most recently modified version published online June 2018).
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n.1956