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单词 topoisomer
释义

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topoisomer
topoisomer n.
Brit. /ˌtɒpəʊˈʌɪsəmə/
,
U.S. /ˌtɑpoʊˈaɪsəmər/
chiefly Biochemistry a topologically distinct isomer.
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topoisomer1979
1972 Chem. Abstr. 76 3466 m (heading) Topological isomers.]
1979 Proc. National Acad. Sci. U.S.A. 76 200 If a nicked circular DNA is converted to the covalently closed form by ligase, the resulting topological isomers (topoisomers) differing only in their linking numbers (topological winding numbers) can be resolved by gel electrophoresis.
1982 Jrnl. Molecular Biol. 155 177 This value has been obtained by titrating the number of pyrimidine dimers necessary to reduce the number of superhelical turns by one in each topoisomer obtained by treatment of a supercoiled DNA with DNA topoisomerase I.
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