单词 | thrombospondin |
释义 | > as lemmasthrombospondin thrombospondin n. Brit. /ˌθrɒmbə(ʊ)ˈspɒndɪn/ , U.S. /ˌθrɑmboʊˈspɑndən/ any of a family of glycoproteins secreted into the extracellular matrix by various types of cell, which play a role in cellular adhesion in processes including thrombocyte aggregation, tumour metastasis, and angiogenesis.ΚΠ 1978 J. W. Lawler et al. in Jrnl. Biol. Chem. 253 8615/2 Thrombospondin is a filamentous molecule about 70 nm long and 3 to 7 nm wide. 1992 P. R. Crocker & G. Milon in C. E. Lewis & J. O'D. McGee Macrophage iii. 136 Components of the extracellular matrix may also interact directly with receptors expressed on the surface of immature haematopoietic cells, as shown for fibronectin, haemonectin, and thrombospondin. 2009 Pittsburgh Tribune Rev. (Nexis) 22 Oct. The researchers blocked a molecule—called thrombospondin-1—from binding to its cell surface receptor—called CD47—something that caused the tumors to become more sensitive to radiation. < as lemmas |
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