thrombogenn.adj.

Brit.

/ˈθrɒmbə(ʊ)dʒ(ə)n/,

/ˈθrɒmbə(ʊ)dʒɛn/, U.S.

/ˈθrɑmbədʒ(ə)n/,

/ˈθrɑmbəˌdʒɛn/

Origin: A borrowing from Greek, combined with English elements. Etymons: Greek θρόμβος , -o- connective, -gen comb. form.

Etymology: < ancient Greek θρόμβος lump, clot of blood, curd of milk (see thrombus n.) + -o- connective + -gen comb. form. Compare thrombogenic adj. In sense A. 2 after German Thrombogen (1903 or earlier).

A. n. Biochemistry.

†1. An enzyme that causes the formation of curds; a rennin. Cf. thrombogenic adj. 1. Obsolete. rare.

ΘΚΠ

the world > life > the body > secretory organs > secretion > gastric juice > [noun] > substance in

pepsin1844

pepsinogen1877

rennin1889

propeptone1890

thrombogen1890

intrinsic factor1930

1890 H. E. Armstrong in Brewers' Guardian 24 June 207/1 I would suggest that we should term the rennets thrombogenic enzymes, or thrombogens.

2. A precursor of thrombin; spec. = prothrombin n. Now historical and rare.

ΘΚΠ

the world > life > the body > vascular system > blood > components of blood > [noun] > other components

iron1799

blood iron1858

prothrombin1898

thrombogen1904

chylomicron1921

myeloperoxidase1943

prealbumin1953

vitellogenin1969

1904 Post-graduate 19 879 We will be able to determine which of the two factors,—the thrombogen or the kinase,—is attacked by them [sc. antithrombines].

1914 Lancet 28 Mar. 878/2 Mellanby and Morawitz showed that normal blood plasma contains a globulin, fibrinogen, together with calcium salts and a substance of unknown composition designated prothrombin or thrombogen.

1928 Tubercle 9 514 For the conversion of fibrinogen into fibrin (clotting) the presence of the enzyme thrombin is needed, and this in turn depends for its production on a mother substance, pro-thrombin (or thrombogen).

2008 Haemophilia 14 1176/1 Morawitz may have been the first to isolate factor (F)X in 1905 when he identified a factor named ‘thromboplastin’ that interacted with ‘thrombogen’ to form thrombin.

†B. adj.

Producing clots or thrombi; thrombogenic. Obsolete. rare.Apparently only attested in dictionaries or glossaries.

ΚΠ

1899 New Sydenham Soc. Lexicon Thrombogen, producing or giving rise to clots.

This entry has been updated (OED Third Edition, March 2017; most recently modified version published online March 2022).

单词	thrombogen
释义	thrombogenn.adj. Brit. /ˈθrɒmbə(ʊ)dʒ(ə)n/, /ˈθrɒmbə(ʊ)dʒɛn/, U.S. /ˈθrɑmbədʒ(ə)n/, /ˈθrɑmbəˌdʒɛn/ Origin: A borrowing from Greek, combined with English elements. Etymons: Greek θρόμβος , -o- connective, -gen comb. form. Etymology: < ancient Greek θρόμβος lump, clot of blood, curd of milk (see thrombus n.) + -o- connective + -gen comb. form. Compare thrombogenic adj. In sense A. 2 after German Thrombogen (1903 or earlier). A. n. Biochemistry. †1. An enzyme that causes the formation of curds; a rennin. Cf. thrombogenic adj. 1. Obsolete. rare. ΘΚΠ the world > life > the body > secretory organs > secretion > gastric juice > [noun] > substance in pepsin1844 pepsinogen1877 rennin1889 propeptone1890 thrombogen1890 intrinsic factor1930 1890 H. E. Armstrong in Brewers' Guardian 24 June 207/1 I would suggest that we should term the rennets thrombogenic enzymes, or thrombogens. 2. A precursor of thrombin; spec. = prothrombin n. Now historical and rare. ΘΚΠ the world > life > the body > vascular system > blood > components of blood > [noun] > other components iron1799 blood iron1858 prothrombin1898 thrombogen1904 chylomicron1921 myeloperoxidase1943 prealbumin1953 vitellogenin1969 1904 Post-graduate 19 879 We will be able to determine which of the two factors,—the thrombogen or the kinase,—is attacked by them [sc. antithrombines]. 1914 Lancet 28 Mar. 878/2 Mellanby and Morawitz showed that normal blood plasma contains a globulin, fibrinogen, together with calcium salts and a substance of unknown composition designated prothrombin or thrombogen. 1928 Tubercle 9 514 For the conversion of fibrinogen into fibrin (clotting) the presence of the enzyme thrombin is needed, and this in turn depends for its production on a mother substance, pro-thrombin (or thrombogen). 2008 Haemophilia 14 1176/1 Morawitz may have been the first to isolate factor (F)X in 1905 when he identified a factor named ‘thromboplastin’ that interacted with ‘thrombogen’ to form thrombin. †B. adj. Producing clots or thrombi; thrombogenic. Obsolete. rare.Apparently only attested in dictionaries or glossaries. ΚΠ 1899 New Sydenham Soc. Lexicon Thrombogen, producing or giving rise to clots. This entry has been updated (OED Third Edition, March 2017; most recently modified version published online March 2022). < n.adj.1890
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