thrombo-comb. form

Stress is usually determined by a subsequent element and vowels may be reduced accordingly.

Forms: before a vowel also thromb-.

Origin: Formed within English, by derivation. Etymons: thrombus n., -o- connective.

Etymology: < thrombus n. + -o- connective.Attested in a number of formations in medicine from the 1st half of the 19th cent. onwards, earliest in thrombocyst n. , an adaptation of a scientific Latin word. From the 2nd half of the 19th cent., also found in a number adaptations of German words, earliest in thrombophlebitis n. and thrombocyte n. In the 20th cent. adaptations of French words are also found, as e.g. thromboplastic adj. , thromboendarterectomy n. Combines chiefly with elements of Latin and Greek origin. Compare scientific Latin thrombo- (formations in which are found from at least the early 19th cent.), French thrombo-, German thrombo-.

Medicine, Surgery, and Biochemistry.

Forming terms relating to a thrombus (blood clot), the formation of a thrombus, and (more generally) the clotting of blood.

thrombasthenia n.

Brit.

/ˌθrɒmbasˈθiːnɪə/

/ˌθrɒmbəsˈθiːnɪə/

U.S.

/ˌθrɑmbəsˈθiniə/

(also thromboasthenia) [ < thrombo- comb. form + asthenia n., after German Thrombasthenie (E. Glanzmann 1918, in Jahrb. f. Kinderheilkunde 88 28)] impaired function of thrombocytes, esp. in regard to aggregation and clot retraction; any condition characterized by this, spec. (more fully hereditary haemorrhagic thrombasthenia or Glanzmann('s) thrombasthenia) an inherited (autosomal recessive) disorder manifesting itself mainly as episodes of bleeding from the mucosal surfaces of the nose, uterus, and gastrointestinal tract.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > defective clotting

thrombasthenia1921

1921 Jrnl. Amer. Med. Assoc. 12 Nov. 1607/1 Others have published results of research on the pathology of the platelets which have demonstrated essential thrombopenia and thrombasthenia.

1935 L. E. H. Whitby & C. J. C. Britton Disorders Blood xiv. 276 (heading) Hereditary hæmorrhagic thrombasthenia.

1993 Brit. Med. Jrnl. 17 July 143/1 Fetal blood sampling was developed for the prenatal diagnosis of hereditary disease—initially the haemoglobinopathies and then the haemophilias, thrombasthenias, metabolic disorders, and immunodeficiencies.

2006 Human Mutation 27 359 The molecular basis of Glanzmann thrombasthenia (GT) was studied in 40 families from southern India.

thrombasthenic adj.

Brit.

/ˌθrɒmbasˈθɛnɪk/

/ˌθrɒmbəsˈθɛnɪk/

U.S.

/ˌθrɑmbəsˈθɛnɪk/

(also thromboasthenic) [ < thrombo- comb. form + asthenic adj., after German thrombasthenisch (1918)] of, relating to, or associated with thrombasthenia; affected with or characterized by thrombasthenia.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [adjective] > defective clotting

thrombasthenic1922

1922 Internat. Med. & Surg. Surv. 3 No. 5. v. 1116 Individuals who present a thrombasthenic constitution.

1966 Amer. Jrnl. Med. 41 19/1 The adsorbed platelet proactivator of plasminogen was more readily eluted by washing from platelets of thrombasthenic patients than from normal patients.

2009 M. P. Lambert & M. Poncz in S. H. Orkin et al. Nathan & Oski's Hematol. Infancy & Childhood (ed. 7) xxix. 1468/1 The earliest and largest group of thrombasthenic mutations described failed to express α_IIbβ₃ on the cell surface.

thrombectomy n.

Brit.

/θrɒmˈbɛktəmi/

U.S.

/θrɑmˈbɛktəmi/

surgical removal of a thrombus or thromboembolus from a blood vessel; an instance of this.

ΘΚΠ

the world > health and disease > healing > medical treatment > surgery > operations on specific parts or conditions > [noun] > operations on vessels

perplication1656

angiotomy1706

aneurysmectomy1909

thrombectomy1909

recanalization1913

thromboendarterectomy1948

endarterectomy1950

1909 Ann. Surg. 50 349 It will be seen..that the operation of thrombectomy or embolectomy, if it may be so called, can be readily performed without danger of secondary hemorrhage.

1945 Urol. & Cutaneous Rev. 40 672/2 Thrombectomy is an extremely difficult and daring operation..but..in thrombosis of the renal vein prompt surgical intervention offers the only hope for a cure.

2010 Brit. Med. Jrnl. 30 Jan. 228/2 Intra-arterial thrombolysis, thrombectomy, vertebral angioplasty, and hemicraniectomy are available and have been delivered for appropriate patients.

thromboarteritis n.

Brit.

/ˌθrɒmbəʊɑːtəˈrʌɪtᵻs/

U.S.

/ˌθrɑmboʊˌɑrdəˈraɪdᵻs/

inflammation and thrombosis of an artery or arteries; an instance of this.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > vascular disorders > [noun] > inflammation

white leg1801

arteritis1820

phlebitis1826

aortitis1842

angiitis1844

mesoarteritis1857

periarteritis1857

periphlebitis1857

pylephlebitis1857

thrombophlebitis1873

thromboarteritis1887

periarteritis nodosa1892

vasculitis1900

polyarteritis1907

thromboangiitis obliterans1908

Buerger's disease1914

Takayasu's disease1952

1887 Philadelphia Med. Times 3 Sept. 787/1 They initiate a septic thrombo-arteritis.

1969 Brit. Med. Jrnl. 18 Jan. 136/1 An interesting case of thromboarteritis of the left brachial artery developing in a 28-year-old radio operator two and a half years after the accidental contact of his left elbow with a capacitator.

2011 Vet. Parasitol. 176 385/1 Vascular lesions due to the presence of adult worms include thromboarteritis and intimal proliferation.

† thrombocyst n. [ < thrombo- comb. form + cystis n., after scientific Latin thrombocystis (1831 or earlier)] Obsolete rare a cyst or membranous sac containing clotted blood.Apparently only attested in dictionaries or glossaries.

ΘΚΠ

the world > health and disease > ill health > a disease > growth or excrescence > [noun] > cyst

wenc1000

crop1599

steatoma1599

hydatid1683

atheroma1706

cyst1731

sac1802

hygroma1813

galactocele1850

dacryops1857

ovule of Naboth1857

hydatid of Morgagni1858

thrombocyst1860

monocyst1869

cystoid1872

cystoma1876

sarcocyst1892

Baker's cyst1893

milk thrombus1895

sweat-cyst1898

tubulocystc1900

sweat vesicle1901

seroma1919

macrocyst1953

macrocyst1980

1860 R. G. Mayne Expos. Lexicon Med. Sci. 1274/2 Thrombocystis, a cyst or membrane containing a clot of blood: a thrombocyst.

thromboembolic adj.

Brit.

/ˌθrɒmbəʊɛmˈbɒlɪk/

U.S.

/ˌθrɑmboʊˌɛmˈbɑlɪk/

[ < thrombo- comb. form + embolic adj., after German thrombo-embolisch (1901 or earlier)] of, relating to, or of the nature of thromboembolism; caused by thromboembolism.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > vascular disorders > [adjective] > embolism

embolic1874

thromboembolic1902

1902 Amer. Med. 23 Aug. 316/2 The simple bacterial forms of pyemia in contradistinction to the thromboembolic form.

1981 Brit. Med. Jrnl. 7 Feb. 466/2 The best approach to the prophylaxis of thromboembolic disease is through low-dose heparin.

2003 S. J. Segal & L. Mastroianni Hormone Use Menopause & Male Andropause 32 The other condition in the FDA's list of definite contraindications to HT is active thrombophlebitis or thromboembolic disorders.

thromboembolism n.

Brit.

/ˌθrɒmbəʊˈɛmbəlɪz(ə)m/

U.S.

/ˌθrɑmboʊˈɛmbəˌlɪz(ə)m/

embolization of a blood vessel by a thrombus or part of a thrombus dislodged from its site of formation; an instance of this; (also) an embolus of this kind (= thromboembolus n.).

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > vascular disorders > [noun] > embolism

embolism1870

pneumathaemia1876

rider1885

thromboembolism1895

embolization1949

1895 Brit. Med. Jrnl. 3 Aug. 20/3 These parenchymatous changes are due to circulatory disturbances—stasis, thrombosis, thrombo-embolism.

1970 Daily Tel. 17 July 2/8 Investigations showed that the increased risk of thrombo-embolism declined rapidly after the patient stopped taking the pill.

2002 Times 7 Mar. 3/4 Just as the brain can suffer irreversible damage from infarction after obstruction to a blood vessel by a thrombo embolism, or clot, so can the spinal cord.

thromboembolus n.

Brit.

/ˌθrɒmbəʊˈɛmbələs/

U.S.

/ˌθrɑmboʊˈɛmbələs/

an embolus consisting of a thrombus, or part of a thrombus, which has become dislodged from its site of formation.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > vascular disorders > [noun] > embolism > an embolism

embolus1876

air embolism1877

embolon1878

embolism1902

thromboembolus1927

saddle thrombus1933

saddle embolus1935

1927 Amer. Jrnl. Surg. 3 281/1 Bone tissue, because of its peculiarities in vascular structure, seems particularly prone to the blocking of these thrombo-emboli.

1977 Lancet 29 Jan. 251/2 Fulton and Duckett report a significant correlation between high plasma-fibrogen levels..and thromboemboli.

2002 Cat Fancy May 53/2 Cats can develop blood clots (thromboemboli) that lodge in veins and impair circulation to their limbs.

thromboendarterectomy n.

Brit.

/ˌθrɒmbəʊɛndɑːtəˈrɛktəmi/

U.S.

/ˌθrɑmboʊˌɛndɑrdəˈrɛktəmi/

(also thrombendarterectomy, thromboendarteriectomy) [ < thrombo- comb. form + endarterectomy n. at endo- prefix and comb. form , after French thrombo-endartériectomie (1948 or earlier)] surgical removal of a thrombus from an artery along with part of the vessel's inner lining (endothelium); an instance of this; cf. thrombectomy n., endarterectomy n. at endo- prefix and comb. form .

ΘΚΠ

the world > health and disease > healing > medical treatment > surgery > operations on specific parts or conditions > [noun] > operations on vessels

perplication1656

angiotomy1706

aneurysmectomy1909

thrombectomy1909

recanalization1913

thromboendarterectomy1948

endarterectomy1950

1948 Q. Cumulative Index Medicus 44 1204/2 Aneurysmal development [in the femoral artery] after dos Santos thromboendarteriectomy.

1974 J. D. Maynard in R. M. Kirk et al. Surgery xi. 235/1 Thrombo-endarterectomy is successful in over 90 per cent of patients with disease above the inguinal ligaments.

2006 Ann. Thoracic Surg. 82 2157/2 The use of intermittent flow periods with DHCA [= deep hypothermic circulatory arrest], employed in pulmonary endarterectomies since the 1980's.

thrombokinase n.

Brit.

/ˌθrɒmbə(ʊ)ˈkʌɪneɪz/

U.S.

/ˌθrɑmboʊˈkaɪˌneɪs/

/ˌθrɑmboʊˈkaɪˌneɪz/

[ < thrombo- comb. form + kinase n., after German Thrombokinase (1903 or earlier)] a substance that promotes clotting, spec. (a) an enzyme that converts prothrombin to thrombin, or the inactive precursor of this; (b) thromboplastin.

ΚΠ

1905 Amer. Year-bk. Med. & Surg.: Med. 518 Thrombokinase is supposed to activate thrombogen, changing it into effective fibrin-ferment.

1968 Biochimica et Biophysica Acta 167 386 The studies reported here have shown that human thrombokinase will, in the absence of any other added reagent, convert prothrombin to thrombin.

2013 Nanomedicine 8 775/1 TF [= tissue factor] (also known as CD142, thrombokinase and factor III) is a transmembrane protein that, when expressed in its active conformation on the cell surface, interacts with coagulation factor VIIa to initiate the plasma coagulation cascade.

thrombopenia n.

Brit.

/ˌθrɒmbə(ʊ)ˈpiːnɪə/

U.S.

/ˌθrɑmbəˈpiniə/

[ < thrombo- comb. form + -penia comb. form, after German Thrombopenie (1915 or earlier)] reduction of the number of thrombocytes in the blood; an instance of this; = thrombocytopenia n.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > deficiency of other substances

hypinosis1845

anaemotrophy1860

hypoglycaemia1894

hypoleucocytosis1897

acapnia1898

leucopenia1898

hypothyroidism1905

hypocapnia1908

lymphopenia1909

hypoparathyroidism1910

neutropenia1915

thrombopenia1915

thrombocytopenia1921

agranulocytosis1923

hypocalcaemia1925

insulin shock1925

hypochloraemia1927

granulocytopenia1931

hypopotassaemia1932

hypomagnesaemia1933

hypoproteinaemia1934

hyponatraemia1935

hypophosphataemia1935

hypoprothrombinaemia1936

hypoalbuminaemia1937

sideropenia1938

afibrinogenaemia1941

pancytopenia1941

hypokalaemia1949

agammaglobulinaemia1952

hypogammaglobulinaemia1955

haemoglobinopathy1957

1915 Med. Rec. 6 Nov. 799/2 Aleukia Hemorrhagica—Frank writes at length on this subject, in association with aplastic anemia and thrombopenia.

1915 Index Medicus 13 Subj. Index 166/1 Thrombopenia.

1922 Nature 20 May 666/1 The absence of the fat-soluble vitamin from the diet leads, in the rat,..to a progressive diminution in the number of blood-platelets known as thrombopenia.

2009 J. Nizard et al. in M. I. Levene & F. A. Chervenak Fetal & Neonatal Neurol. & Neurosurg. (ed. 4) xxx. 636/1 Pyrimethanine is a folic acid antagonist. It can therefore depress the bone marrow and give most often only a macrocytic anemia, neutropenia or thrombopenia.

thrombopenic adj.

Brit.

/ˌθrɒmbə(ʊ)ˈpiːnɪk/

U.S.

/ˌθrɑmbəˈpinɪk/

characterized or caused by thrombopenia; affected with thrombopenia; = thrombocytopenic adj. at thrombocytopenia n. Derivatives.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [adjective] > deficiency of other substances

dispirited1740

hypinotic1855

hypoglycaemic1923

thrombocytopenic1923

thrombopenic1924

neutropenic1932

hypocalcaemic1935

hypoproteinaemic1935

sideropenic1939

hypoprothrombinaemic1942

hypophosphataemic1946

hypopotassaemic1950

hypokalaemic1953

agammaglobulinaemic1954

hyponatraemic1955

hypomagnesaemic1960

1924 Lancet 2 Aug. 229/1 (heading) Thrombopenic anæmia and splenectomy.

1937 Brit. Med. Jrnl. 20 Feb. Epitome 32/2 Abnormal stability of the platelets was found in thrombopenias, as in scurvy, nephrosclerosis, etc.

2006 P. Menu et al. in P. Hervé et al. Transfusion Med. 120 In vivo, the hemostatic properties of these rehydrated platelets were demonstrated in studies on thrombopenic animals (rabbits and dogs); however, activity duration was short.

thrombophilia n.

Brit.

/ˌθrɒmbə(ʊ)ˈfɪlɪə/

U.S.

/ˌθrɑmbəˈfɪliə/

/ˌθrɑmboʊˈfɪliə/

[ < thrombo- comb. form + -philia comb. form, after German Thrombophilie (F. Mendel 1909, in Münchener med. Wochenschr. 19 Oct. 2149/2)] predisposition to the formation of thrombi; thrombotic diathesis; an instance of this.

ΚΠ

1909 Jrnl. Amer. Med. Assoc. 4 Dec. 1952/1 Mendel applies the term ‘thrombophilia’ to a predisposition to formation of thrombi which some patients seem to display—the exact reverse of hemophilia.

1976 L. A. Harker in Animal Models Thrombosis & Hemorrhagic Dis. (U.S. Dept. Health, Educ. & Welfare) 203 Hereditary thrombophilia in the venous system is reported in families demonstrating antithrombin III deficiency.

2003 Guardian 8 Apr. ii. 14/2 The good news is that a new blood test has been developed to identify those whose blood has a predisposition to clot—thrombophilia.

thrombophlebitis n.

Brit.

/ˌθrɒmbə(ʊ)flᵻˈbʌɪtᵻs/

U.S.

/ˌθrɑmboʊfləˈbaɪdᵻs/

[ < thrombo- comb. form + phlebitis n., after German Thrombophlebitis (1867 or earlier)] inflammation and thrombosis of a vein or veins; an instance of this; cf. phlebothrombosis n. at phlebo- comb. form .

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > vascular disorders > [noun] > inflammation

white leg1801

arteritis1820

phlebitis1826

aortitis1842

angiitis1844

mesoarteritis1857

periarteritis1857

periphlebitis1857

pylephlebitis1857

thrombophlebitis1873

thromboarteritis1887

periarteritis nodosa1892

vasculitis1900

polyarteritis1907

thromboangiitis obliterans1908

Buerger's disease1914

Takayasu's disease1952

1873 Brit. Jrnl. Homœopathy 31 35 Ichorous femoral thrombo-phlebitis.

1939 A. Ochsuer in Surgery 6 129 In considering intravascular clotting, it is important to distinguish between those lesions which are associated with an inflammatory process in the vessel wall, a true thrombophlebitis, and those in which there is intravascular clotting without the associated inflammatory lesion which can be termed a ‘phlebothrombosis’.

2006 J. C. Buckley Space Physiol. x. 212 To minimize the risk of thrombophlebitis, women who take estrogen also should be screened for conditions that might increase the likelihood of blood clots (such as factor V Leiden, protein C, and protein S deficiency).

thromboplastic adj.

Brit.

/ˌθrɒmbə(ʊ)ˈplastɪk/

U.S.

/ˌθrɑmboʊˈplæstɪk/

[ < thrombo- comb. form + -plastic comb. form, after French thromboplastique (1908 or earlier)] promoting the clotting of blood.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [adjective] > clotting > causing

thromboplastic1908

1908 Chem. Abstr. 2 3089 Many cells, however, contain substances which facilitate the clotting, and these various substances the author calls thromboplastic compounds.

1911 W. H. Howell in Amer. Jrnl. Physiol. 29 189 They [sc. tissue extracts] furnish a substance, which may be designated as a thromboplastic substance or thromboplastin.

1981 Obstetrics & Gynecol. 57 490/2 Acceleration of the rate of clotting of whole blood is due to the thromboplastic activity of amniotic fluid.

2015 Acta Biomaterialia 15 264/1 Hemolysis can cause the release of hemoglobin, intracellular components and thromboplastic substances from ruptured erythrocytes.

thromboplastin n.

Brit.

/ˌθrɒmbə(ʊ)ˈplastɪn/

U.S.

/ˌθrɑmboʊˈplæstən/

a thromboplastic substance, esp. one that plays a role in the activation of thrombin; spec. (more fully tissue thromboplastin) a protein produced in tissues outside the vascular system that plays such a role (also called tissue factor).

ΚΠ

1911 W. H. Howell in Amer. Jrnl. Physiol. 29 189 They [sc. tissue extracts] furnish a substance, which may be designated as a thromboplastic substance or thromboplastin.

1954 R. G. Macfarlane in H. W. Florey Lect. Gen. Pathol. x. 196 The classical theory, built up during the past fifty years, postulates a direct stimulator of prothrombin conversion which is usually called ‘thromboplastin’.

2003 Jrnl. Avian Med. & Surg. 17 73/1 Tissue thromboplastin, in conjunction with calcium and phospholipid, mediates the generation of thrombin from prothrombin.

thrombopoiesis n.

Brit.

/ˌθrɒmbə(ʊ)pɔɪˈiːsɪs/

U.S.

/ˌθrɑmboʊˌpɔɪˈisᵻs/

the production of thrombocytes; cf. erythropoiesis n., leucopoiesis n. at leuco- comb. form 1.

ΚΠ

1922 Internat. Med. & Surg. Surv. 4 No. 1. v. 1167 In one case described there was a toxic blood picture, a severe injury of leukopoiesis, erythropoiesis and thrombopoiesis.

1979 Amer. Zoologist 19 856/1 Normal animals [sc. urodeles of the species Pleurodeles waltlii] showed erythropoiesis and thrombopoiesis in splenic red pulp.

2016 T. Colville & J. M. Bassert Clin. Anat. & Physiol. for Vet. Technicians (ed. 3) xii. 298/1 Thrombopoiesis can take up to 7 days to reach completion.

thrombopoietin n.

Brit.

/ˌθrɒmbə(ʊ)pɔɪˈɛtɪn/

/ˌθrɒmbə(ʊ)ˈpɔɪᵻtɪn/

U.S.

/ˌθrɑmboʊˈpɔɪətn/

a protein made in the kidney and liver that stimulates the proliferation and differentiation of megakaryocytes in bone marrow, increasing the production of thrombocytes; cf. erythropoietin n.

ΚΠ

1958 E. Kelemen et al. in Acta Haematologica 20 351 The investigation of haemopoietins is an old topic of the haematological literature. The possible existence of thrombopoietin was, however, rarely examined.

1994 N.Y. Times 16 July d23 The pigs began making thrombopoietin to replenish their platelets.

2014 S. Chakravorty & I. Roberts in A. E. Thomas & C. Halsey Controv. Pediatric & Adolescent Hematol. i. 4 Fetal megakaryocytes have more proliferative potential in vitro than those derived from adults and are more sensitive to thrombopoietin.

thrombospondin n.

Brit.

/ˌθrɒmbə(ʊ)ˈspɒndɪn/

U.S.

/ˌθrɑmboʊˈspɑndən/

any of a family of glycoproteins secreted into the extracellular matrix by various types of cell, which play a role in cellular adhesion in processes including thrombocyte aggregation, tumour metastasis, and angiogenesis.

ΚΠ

1978 J. W. Lawler et al. in Jrnl. Biol. Chem. 253 8615/2 Thrombospondin is a filamentous molecule about 70 nm long and 3 to 7 nm wide.

1992 P. R. Crocker & G. Milon in C. E. Lewis & J. O'D. McGee Macrophage iii. 136 Components of the extracellular matrix may also interact directly with receptors expressed on the surface of immature haematopoietic cells, as shown for fibronectin, haemonectin, and thrombospondin.

2009 Pittsburgh Tribune Rev. (Nexis) 22 Oct. The researchers blocked a molecule—called thrombospondin-1—from binding to its cell surface receptor—called CD47—something that caused the tumors to become more sensitive to radiation.

thrombosthenin n.

Brit.

/ˌθrɒmbə(ʊ)ˈsθiːnɪn/

U.S.

/ˌθrɑmboʊˈsθinən/

[ < thrombo- comb. form + ancient Greek σθένος strength (see asthenia n.) + -in suffix¹] contractile protein (actin and myosin) found in thrombocytes, playing a functional role in their aggregation and their compaction of fibrin clots.

ΘΚΠ

the world > life > the body > vascular system > blood > components of blood > blood corpuscle or plate > [noun] > part of

hyalomere1936

thrombosthenin1961

1961 M. Bettex-Galland & E. F. Lüscher in Biochimica et Biophysica Acta 49 537 We have named this protein ‘thrombosthenin’, firstly because of its role in thrombocyte function, and secondly because of its properties, which in many respects let it appear distinct from muscle actomyosin.

1974 Encycl. Brit. Macropædia II. 1107/2 They [sc. platelets]..contain..a contractile protein (thrombosthenin) that allows platelets to extend and retract long footlike projections called pseudopodia.

2008 Jrnl. Med. Engin. & Physics 30 673/2 They consider that the retraction of thrombosthenin in platelets incorporated within the network stretches the fibrin fibres.

thromboxane n.

Brit.

/θrɒmˈbɒkseɪn/

U.S.

/θrɑmˈbɑkˌseɪn/

[ < thrombo- comb. form + ox- (in oxy- comb. form²) + -ane suffix²] any of a class of compounds structurally related to prostaglandins, the major member of which is synthesized in thrombocytes and promotes their aggregation.

ΚΠ

1975 Nature 3 July 14/1 This new intermediate does not have a classical prostaglandin structure and has been named ‘Thromboxane’.., because it is a very potent platelet aggregating agent. Since it is the first member of a new series of compounds and contains two double bonds it was further designated ‘Thromboxane A₂’: its metabolite..becomes ‘Thromboxane B₂.’

1979 Nature 6 Sept. 14/3 Because of their fish diet, Greenland Eskimos have high plasma levels of eicosapentenoic acid which is the precursor of the three series of endoperoxides—prostaglandins, thromboxane and prostacyclin.

2010 B. J. Bain Haematology xi. 221 The membrane lipid is also the source of arachidonic acid, which is converted by cyclo-oxygenase to thromboxane A2, a potent aggregant.

This entry has been updated (OED Third Edition, March 2017; most recently modified version published online March 2022).

单词	thrombo-
释义	thrombo-comb. form Stress is usually determined by a subsequent element and vowels may be reduced accordingly. Forms: before a vowel also thromb-. Origin: Formed within English, by derivation. Etymons: thrombus n., -o- connective. Etymology: < thrombus n. + -o- connective.Attested in a number of formations in medicine from the 1st half of the 19th cent. onwards, earliest in thrombocyst n. , an adaptation of a scientific Latin word. From the 2nd half of the 19th cent., also found in a number adaptations of German words, earliest in thrombophlebitis n. and thrombocyte n. In the 20th cent. adaptations of French words are also found, as e.g. thromboplastic adj. , thromboendarterectomy n. Combines chiefly with elements of Latin and Greek origin. Compare scientific Latin thrombo- (formations in which are found from at least the early 19th cent.), French thrombo-, German thrombo-. Medicine, Surgery, and Biochemistry. Forming terms relating to a thrombus (blood clot), the formation of a thrombus, and (more generally) the clotting of blood. thrombasthenia n. Brit. /ˌθrɒmbasˈθiːnɪə/ , /ˌθrɒmbəsˈθiːnɪə/ , U.S. /ˌθrɑmbəsˈθiniə/ (also thromboasthenia) [ < thrombo- comb. form + asthenia n., after German Thrombasthenie (E. Glanzmann 1918, in Jahrb. f. Kinderheilkunde 88 28)] impaired function of thrombocytes, esp. in regard to aggregation and clot retraction; any condition characterized by this, spec. (more fully hereditary haemorrhagic thrombasthenia or Glanzmann('s) thrombasthenia) an inherited (autosomal recessive) disorder manifesting itself mainly as episodes of bleeding from the mucosal surfaces of the nose, uterus, and gastrointestinal tract. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > defective clotting thrombasthenia1921 1921 Jrnl. Amer. Med. Assoc. 12 Nov. 1607/1 Others have published results of research on the pathology of the platelets which have demonstrated essential thrombopenia and thrombasthenia. 1935 L. E. H. Whitby & C. J. C. Britton Disorders Blood xiv. 276 (heading) Hereditary hæmorrhagic thrombasthenia. 1993 Brit. Med. Jrnl. 17 July 143/1 Fetal blood sampling was developed for the prenatal diagnosis of hereditary disease—initially the haemoglobinopathies and then the haemophilias, thrombasthenias, metabolic disorders, and immunodeficiencies. 2006 Human Mutation 27 359 The molecular basis of Glanzmann thrombasthenia (GT) was studied in 40 families from southern India. thrombasthenic adj. Brit. /ˌθrɒmbasˈθɛnɪk/ , /ˌθrɒmbəsˈθɛnɪk/ , U.S. /ˌθrɑmbəsˈθɛnɪk/ (also thromboasthenic) [ < thrombo- comb. form + asthenic adj., after German thrombasthenisch (1918)] of, relating to, or associated with thrombasthenia; affected with or characterized by thrombasthenia. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [adjective] > defective clotting thrombasthenic1922 1922 Internat. Med. & Surg. Surv. 3 No. 5. v. 1116 Individuals who present a thrombasthenic constitution. 1966 Amer. Jrnl. Med. 41 19/1 The adsorbed platelet proactivator of plasminogen was more readily eluted by washing from platelets of thrombasthenic patients than from normal patients. 2009 M. P. Lambert & M. Poncz in S. H. Orkin et al. Nathan & Oski's Hematol. Infancy & Childhood (ed. 7) xxix. 1468/1 The earliest and largest group of thrombasthenic mutations described failed to express α_IIbβ₃ on the cell surface. thrombectomy n. Brit. /θrɒmˈbɛktəmi/ , U.S. /θrɑmˈbɛktəmi/ surgical removal of a thrombus or thromboembolus from a blood vessel; an instance of this. ΘΚΠ the world > health and disease > healing > medical treatment > surgery > operations on specific parts or conditions > [noun] > operations on vessels perplication1656 angiotomy1706 aneurysmectomy1909 thrombectomy1909 recanalization1913 thromboendarterectomy1948 endarterectomy1950 1909 Ann. Surg. 50 349 It will be seen..that the operation of thrombectomy or embolectomy, if it may be so called, can be readily performed without danger of secondary hemorrhage. 1945 Urol. & Cutaneous Rev. 40 672/2 Thrombectomy is an extremely difficult and daring operation..but..in thrombosis of the renal vein prompt surgical intervention offers the only hope for a cure. 2010 Brit. Med. Jrnl. 30 Jan. 228/2 Intra-arterial thrombolysis, thrombectomy, vertebral angioplasty, and hemicraniectomy are available and have been delivered for appropriate patients. thromboarteritis n. Brit. /ˌθrɒmbəʊɑːtəˈrʌɪtᵻs/ , U.S. /ˌθrɑmboʊˌɑrdəˈraɪdᵻs/ inflammation and thrombosis of an artery or arteries; an instance of this. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > vascular disorders > [noun] > inflammation white leg1801 arteritis1820 phlebitis1826 aortitis1842 angiitis1844 mesoarteritis1857 periarteritis1857 periphlebitis1857 pylephlebitis1857 thrombophlebitis1873 thromboarteritis1887 periarteritis nodosa1892 vasculitis1900 polyarteritis1907 thromboangiitis obliterans1908 Buerger's disease1914 Takayasu's disease1952 1887 Philadelphia Med. Times 3 Sept. 787/1 They initiate a septic thrombo-arteritis. 1969 Brit. Med. Jrnl. 18 Jan. 136/1 An interesting case of thromboarteritis of the left brachial artery developing in a 28-year-old radio operator two and a half years after the accidental contact of his left elbow with a capacitator. 2011 Vet. Parasitol. 176 385/1 Vascular lesions due to the presence of adult worms include thromboarteritis and intimal proliferation. † thrombocyst n. [ < thrombo- comb. form + cystis n., after scientific Latin thrombocystis (1831 or earlier)] Obsolete rare a cyst or membranous sac containing clotted blood.Apparently only attested in dictionaries or glossaries. ΘΚΠ the world > health and disease > ill health > a disease > growth or excrescence > [noun] > cyst wenc1000 crop1599 steatoma1599 hydatid1683 atheroma1706 cyst1731 sac1802 hygroma1813 galactocele1850 dacryops1857 ovule of Naboth1857 hydatid of Morgagni1858 thrombocyst1860 monocyst1869 cystoid1872 cystoma1876 sarcocyst1892 Baker's cyst1893 milk thrombus1895 sweat-cyst1898 tubulocystc1900 sweat vesicle1901 seroma1919 macrocyst1953 macrocyst1980 1860 R. G. Mayne Expos. Lexicon Med. Sci. 1274/2 Thrombocystis, a cyst or membrane containing a clot of blood: a thrombocyst. thromboembolic adj. Brit. /ˌθrɒmbəʊɛmˈbɒlɪk/ , U.S. /ˌθrɑmboʊˌɛmˈbɑlɪk/ [ < thrombo- comb. form + embolic adj., after German thrombo-embolisch (1901 or earlier)] of, relating to, or of the nature of thromboembolism; caused by thromboembolism. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > vascular disorders > [adjective] > embolism embolic1874 thromboembolic1902 1902 Amer. Med. 23 Aug. 316/2 The simple bacterial forms of pyemia in contradistinction to the thromboembolic form. 1981 Brit. Med. Jrnl. 7 Feb. 466/2 The best approach to the prophylaxis of thromboembolic disease is through low-dose heparin. 2003 S. J. Segal & L. Mastroianni Hormone Use Menopause & Male Andropause 32 The other condition in the FDA's list of definite contraindications to HT is active thrombophlebitis or thromboembolic disorders. thromboembolism n. Brit. /ˌθrɒmbəʊˈɛmbəlɪz(ə)m/ , U.S. /ˌθrɑmboʊˈɛmbəˌlɪz(ə)m/ embolization of a blood vessel by a thrombus or part of a thrombus dislodged from its site of formation; an instance of this; (also) an embolus of this kind (= thromboembolus n.). ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > vascular disorders > [noun] > embolism embolism1870 pneumathaemia1876 rider1885 thromboembolism1895 embolization1949 1895 Brit. Med. Jrnl. 3 Aug. 20/3 These parenchymatous changes are due to circulatory disturbances—stasis, thrombosis, thrombo-embolism. 1970 Daily Tel. 17 July 2/8 Investigations showed that the increased risk of thrombo-embolism declined rapidly after the patient stopped taking the pill. 2002 Times 7 Mar. 3/4 Just as the brain can suffer irreversible damage from infarction after obstruction to a blood vessel by a thrombo embolism, or clot, so can the spinal cord. thromboembolus n. Brit. /ˌθrɒmbəʊˈɛmbələs/ , U.S. /ˌθrɑmboʊˈɛmbələs/ an embolus consisting of a thrombus, or part of a thrombus, which has become dislodged from its site of formation. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > vascular disorders > [noun] > embolism > an embolism embolus1876 air embolism1877 embolon1878 embolism1902 thromboembolus1927 saddle thrombus1933 saddle embolus1935 1927 Amer. Jrnl. Surg. 3 281/1 Bone tissue, because of its peculiarities in vascular structure, seems particularly prone to the blocking of these thrombo-emboli. 1977 Lancet 29 Jan. 251/2 Fulton and Duckett report a significant correlation between high plasma-fibrogen levels..and thromboemboli. 2002 Cat Fancy May 53/2 Cats can develop blood clots (thromboemboli) that lodge in veins and impair circulation to their limbs. thromboendarterectomy n. Brit. /ˌθrɒmbəʊɛndɑːtəˈrɛktəmi/ , U.S. /ˌθrɑmboʊˌɛndɑrdəˈrɛktəmi/ (also thrombendarterectomy, thromboendarteriectomy) [ < thrombo- comb. form + endarterectomy n. at endo- prefix and comb. form , after French thrombo-endartériectomie (1948 or earlier)] surgical removal of a thrombus from an artery along with part of the vessel's inner lining (endothelium); an instance of this; cf. thrombectomy n., endarterectomy n. at endo- prefix and comb. form . ΘΚΠ the world > health and disease > healing > medical treatment > surgery > operations on specific parts or conditions > [noun] > operations on vessels perplication1656 angiotomy1706 aneurysmectomy1909 thrombectomy1909 recanalization1913 thromboendarterectomy1948 endarterectomy1950 1948 Q. Cumulative Index Medicus 44 1204/2 Aneurysmal development [in the femoral artery] after dos Santos thromboendarteriectomy. 1974 J. D. Maynard in R. M. Kirk et al. Surgery xi. 235/1 Thrombo-endarterectomy is successful in over 90 per cent of patients with disease above the inguinal ligaments. 2006 Ann. Thoracic Surg. 82 2157/2 The use of intermittent flow periods with DHCA [= deep hypothermic circulatory arrest], employed in pulmonary endarterectomies since the 1980's. thrombokinase n. Brit. /ˌθrɒmbə(ʊ)ˈkʌɪneɪz/ , U.S. /ˌθrɑmboʊˈkaɪˌneɪs/ , /ˌθrɑmboʊˈkaɪˌneɪz/ [ < thrombo- comb. form + kinase n., after German Thrombokinase (1903 or earlier)] a substance that promotes clotting, spec. (a) an enzyme that converts prothrombin to thrombin, or the inactive precursor of this; (b) thromboplastin. ΚΠ 1905 Amer. Year-bk. Med. & Surg.: Med. 518 Thrombokinase is supposed to activate thrombogen, changing it into effective fibrin-ferment. 1968 Biochimica et Biophysica Acta 167 386 The studies reported here have shown that human thrombokinase will, in the absence of any other added reagent, convert prothrombin to thrombin. 2013 Nanomedicine 8 775/1 TF [= tissue factor] (also known as CD142, thrombokinase and factor III) is a transmembrane protein that, when expressed in its active conformation on the cell surface, interacts with coagulation factor VIIa to initiate the plasma coagulation cascade. thrombopenia n. Brit. /ˌθrɒmbə(ʊ)ˈpiːnɪə/ , U.S. /ˌθrɑmbəˈpiniə/ [ < thrombo- comb. form + -penia comb. form, after German Thrombopenie (1915 or earlier)] reduction of the number of thrombocytes in the blood; an instance of this; = thrombocytopenia n. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > deficiency of other substances hypinosis1845 anaemotrophy1860 hypoglycaemia1894 hypoleucocytosis1897 acapnia1898 leucopenia1898 hypothyroidism1905 hypocapnia1908 lymphopenia1909 hypoparathyroidism1910 neutropenia1915 thrombopenia1915 thrombocytopenia1921 agranulocytosis1923 hypocalcaemia1925 insulin shock1925 hypochloraemia1927 granulocytopenia1931 hypopotassaemia1932 hypomagnesaemia1933 hypoproteinaemia1934 hyponatraemia1935 hypophosphataemia1935 hypoprothrombinaemia1936 hypoalbuminaemia1937 sideropenia1938 afibrinogenaemia1941 pancytopenia1941 hypokalaemia1949 agammaglobulinaemia1952 hypogammaglobulinaemia1955 haemoglobinopathy1957 1915 Med. Rec. 6 Nov. 799/2 Aleukia Hemorrhagica—Frank writes at length on this subject, in association with aplastic anemia and thrombopenia. 1915 Index Medicus 13 Subj. Index 166/1 Thrombopenia. 1922 Nature 20 May 666/1 The absence of the fat-soluble vitamin from the diet leads, in the rat,..to a progressive diminution in the number of blood-platelets known as thrombopenia. 2009 J. Nizard et al. in M. I. Levene & F. A. Chervenak Fetal & Neonatal Neurol. & Neurosurg. (ed. 4) xxx. 636/1 Pyrimethanine is a folic acid antagonist. It can therefore depress the bone marrow and give most often only a macrocytic anemia, neutropenia or thrombopenia. thrombopenic adj. Brit. /ˌθrɒmbə(ʊ)ˈpiːnɪk/ , U.S. /ˌθrɑmbəˈpinɪk/ characterized or caused by thrombopenia; affected with thrombopenia; = thrombocytopenic adj. at thrombocytopenia n. Derivatives. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [adjective] > deficiency of other substances dispirited1740 hypinotic1855 hypoglycaemic1923 thrombocytopenic1923 thrombopenic1924 neutropenic1932 hypocalcaemic1935 hypoproteinaemic1935 sideropenic1939 hypoprothrombinaemic1942 hypophosphataemic1946 hypopotassaemic1950 hypokalaemic1953 agammaglobulinaemic1954 hyponatraemic1955 hypomagnesaemic1960 1924 Lancet 2 Aug. 229/1 (heading) Thrombopenic anæmia and splenectomy. 1937 Brit. Med. Jrnl. 20 Feb. Epitome 32/2 Abnormal stability of the platelets was found in thrombopenias, as in scurvy, nephrosclerosis, etc. 2006 P. Menu et al. in P. Hervé et al. Transfusion Med. 120 In vivo, the hemostatic properties of these rehydrated platelets were demonstrated in studies on thrombopenic animals (rabbits and dogs); however, activity duration was short. thrombophilia n. Brit. /ˌθrɒmbə(ʊ)ˈfɪlɪə/ , U.S. /ˌθrɑmbəˈfɪliə/ , /ˌθrɑmboʊˈfɪliə/ [ < thrombo- comb. form + -philia comb. form, after German Thrombophilie (F. Mendel 1909, in Münchener med. Wochenschr. 19 Oct. 2149/2)] predisposition to the formation of thrombi; thrombotic diathesis; an instance of this. ΚΠ 1909 Jrnl. Amer. Med. Assoc. 4 Dec. 1952/1 Mendel applies the term ‘thrombophilia’ to a predisposition to formation of thrombi which some patients seem to display—the exact reverse of hemophilia. 1976 L. A. Harker in Animal Models Thrombosis & Hemorrhagic Dis. (U.S. Dept. Health, Educ. & Welfare) 203 Hereditary thrombophilia in the venous system is reported in families demonstrating antithrombin III deficiency. 2003 Guardian 8 Apr. ii. 14/2 The good news is that a new blood test has been developed to identify those whose blood has a predisposition to clot—thrombophilia. thrombophlebitis n. Brit. /ˌθrɒmbə(ʊ)flᵻˈbʌɪtᵻs/ , U.S. /ˌθrɑmboʊfləˈbaɪdᵻs/ [ < thrombo- comb. form + phlebitis n., after German Thrombophlebitis (1867 or earlier)] inflammation and thrombosis of a vein or veins; an instance of this; cf. phlebothrombosis n. at phlebo- comb. form . ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > vascular disorders > [noun] > inflammation white leg1801 arteritis1820 phlebitis1826 aortitis1842 angiitis1844 mesoarteritis1857 periarteritis1857 periphlebitis1857 pylephlebitis1857 thrombophlebitis1873 thromboarteritis1887 periarteritis nodosa1892 vasculitis1900 polyarteritis1907 thromboangiitis obliterans1908 Buerger's disease1914 Takayasu's disease1952 1873 Brit. Jrnl. Homœopathy 31 35 Ichorous femoral thrombo-phlebitis. 1939 A. Ochsuer in Surgery 6 129 In considering intravascular clotting, it is important to distinguish between those lesions which are associated with an inflammatory process in the vessel wall, a true thrombophlebitis, and those in which there is intravascular clotting without the associated inflammatory lesion which can be termed a ‘phlebothrombosis’. 2006 J. C. Buckley Space Physiol. x. 212 To minimize the risk of thrombophlebitis, women who take estrogen also should be screened for conditions that might increase the likelihood of blood clots (such as factor V Leiden, protein C, and protein S deficiency). thromboplastic adj. Brit. /ˌθrɒmbə(ʊ)ˈplastɪk/ , U.S. /ˌθrɑmboʊˈplæstɪk/ [ < thrombo- comb. form + -plastic comb. form, after French thromboplastique (1908 or earlier)] promoting the clotting of blood. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [adjective] > clotting > causing thromboplastic1908 1908 Chem. Abstr. 2 3089 Many cells, however, contain substances which facilitate the clotting, and these various substances the author calls thromboplastic compounds. 1911 W. H. Howell in Amer. Jrnl. Physiol. 29 189 They [sc. tissue extracts] furnish a substance, which may be designated as a thromboplastic substance or thromboplastin. 1981 Obstetrics & Gynecol. 57 490/2 Acceleration of the rate of clotting of whole blood is due to the thromboplastic activity of amniotic fluid. 2015 Acta Biomaterialia 15 264/1 Hemolysis can cause the release of hemoglobin, intracellular components and thromboplastic substances from ruptured erythrocytes. thromboplastin n. Brit. /ˌθrɒmbə(ʊ)ˈplastɪn/ , U.S. /ˌθrɑmboʊˈplæstən/ a thromboplastic substance, esp. one that plays a role in the activation of thrombin; spec. (more fully tissue thromboplastin) a protein produced in tissues outside the vascular system that plays such a role (also called tissue factor). ΚΠ 1911 W. H. Howell in Amer. Jrnl. Physiol. 29 189 They [sc. tissue extracts] furnish a substance, which may be designated as a thromboplastic substance or thromboplastin. 1954 R. G. Macfarlane in H. W. Florey Lect. Gen. Pathol. x. 196 The classical theory, built up during the past fifty years, postulates a direct stimulator of prothrombin conversion which is usually called ‘thromboplastin’. 2003 Jrnl. Avian Med. & Surg. 17 73/1 Tissue thromboplastin, in conjunction with calcium and phospholipid, mediates the generation of thrombin from prothrombin. thrombopoiesis n. Brit. /ˌθrɒmbə(ʊ)pɔɪˈiːsɪs/ , U.S. /ˌθrɑmboʊˌpɔɪˈisᵻs/ the production of thrombocytes; cf. erythropoiesis n., leucopoiesis n. at leuco- comb. form 1. ΚΠ 1922 Internat. Med. & Surg. Surv. 4 No. 1. v. 1167 In one case described there was a toxic blood picture, a severe injury of leukopoiesis, erythropoiesis and thrombopoiesis. 1979 Amer. Zoologist 19 856/1 Normal animals [sc. urodeles of the species Pleurodeles waltlii] showed erythropoiesis and thrombopoiesis in splenic red pulp. 2016 T. Colville & J. M. Bassert Clin. Anat. & Physiol. for Vet. Technicians (ed. 3) xii. 298/1 Thrombopoiesis can take up to 7 days to reach completion. thrombopoietin n. Brit. /ˌθrɒmbə(ʊ)pɔɪˈɛtɪn/ , /ˌθrɒmbə(ʊ)ˈpɔɪᵻtɪn/ , U.S. /ˌθrɑmboʊˈpɔɪətn/ a protein made in the kidney and liver that stimulates the proliferation and differentiation of megakaryocytes in bone marrow, increasing the production of thrombocytes; cf. erythropoietin n. ΚΠ 1958 E. Kelemen et al. in Acta Haematologica 20 351 The investigation of haemopoietins is an old topic of the haematological literature. The possible existence of thrombopoietin was, however, rarely examined. 1994 N.Y. Times 16 July d23 The pigs began making thrombopoietin to replenish their platelets. 2014 S. Chakravorty & I. Roberts in A. E. Thomas & C. Halsey Controv. Pediatric & Adolescent Hematol. i. 4 Fetal megakaryocytes have more proliferative potential in vitro than those derived from adults and are more sensitive to thrombopoietin. thrombospondin n. Brit. /ˌθrɒmbə(ʊ)ˈspɒndɪn/ , U.S. /ˌθrɑmboʊˈspɑndən/ any of a family of glycoproteins secreted into the extracellular matrix by various types of cell, which play a role in cellular adhesion in processes including thrombocyte aggregation, tumour metastasis, and angiogenesis. ΚΠ 1978 J. W. Lawler et al. in Jrnl. Biol. Chem. 253 8615/2 Thrombospondin is a filamentous molecule about 70 nm long and 3 to 7 nm wide. 1992 P. R. Crocker & G. Milon in C. E. Lewis & J. O'D. McGee Macrophage iii. 136 Components of the extracellular matrix may also interact directly with receptors expressed on the surface of immature haematopoietic cells, as shown for fibronectin, haemonectin, and thrombospondin. 2009 Pittsburgh Tribune Rev. (Nexis) 22 Oct. The researchers blocked a molecule—called thrombospondin-1—from binding to its cell surface receptor—called CD47—something that caused the tumors to become more sensitive to radiation. thrombosthenin n. Brit. /ˌθrɒmbə(ʊ)ˈsθiːnɪn/ , U.S. /ˌθrɑmboʊˈsθinən/ [ < thrombo- comb. form + ancient Greek σθένος strength (see asthenia n.) + -in suffix¹] contractile protein (actin and myosin) found in thrombocytes, playing a functional role in their aggregation and their compaction of fibrin clots. ΘΚΠ the world > life > the body > vascular system > blood > components of blood > blood corpuscle or plate > [noun] > part of hyalomere1936 thrombosthenin1961 1961 M. Bettex-Galland & E. F. Lüscher in Biochimica et Biophysica Acta 49 537 We have named this protein ‘thrombosthenin’, firstly because of its role in thrombocyte function, and secondly because of its properties, which in many respects let it appear distinct from muscle actomyosin. 1974 Encycl. Brit. Macropædia II. 1107/2 They [sc. platelets]..contain..a contractile protein (thrombosthenin) that allows platelets to extend and retract long footlike projections called pseudopodia. 2008 Jrnl. Med. Engin. & Physics 30 673/2 They consider that the retraction of thrombosthenin in platelets incorporated within the network stretches the fibrin fibres. thromboxane n. Brit. /θrɒmˈbɒkseɪn/ , U.S. /θrɑmˈbɑkˌseɪn/ [ < thrombo- comb. form + ox- (in oxy- comb. form²) + -ane suffix²] any of a class of compounds structurally related to prostaglandins, the major member of which is synthesized in thrombocytes and promotes their aggregation. ΚΠ 1975 Nature 3 July 14/1 This new intermediate does not have a classical prostaglandin structure and has been named ‘Thromboxane’.., because it is a very potent platelet aggregating agent. Since it is the first member of a new series of compounds and contains two double bonds it was further designated ‘Thromboxane A₂’: its metabolite..becomes ‘Thromboxane B₂.’ 1979 Nature 6 Sept. 14/3 Because of their fish diet, Greenland Eskimos have high plasma levels of eicosapentenoic acid which is the precursor of the three series of endoperoxides—prostaglandins, thromboxane and prostacyclin. 2010 B. J. Bain Haematology xi. 221 The membrane lipid is also the source of arachidonic acid, which is converted by cyclo-oxygenase to thromboxane A2, a potent aggregant. This entry has been updated (OED Third Edition, March 2017; most recently modified version published online March 2022). < comb. form1860
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