thiazolidinen.
/θʌɪəˈzɒlɪdiːn/ Chemistry and Pharmacology.
(a) A liquid, C3H7NS, whose molecular structure is that of thiazole with an additional hydrogen atom attached to the nitrogen and each carbon atom. (b) Any compound containing this ring structure in its molecule.
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thiazole1888
thiazolidine1916
the world > matter > chemistry > organic chemistry > organic compounds > [noun] > cyclic compounds > named > thiazoles > derivatives
thiazolidine1916
spinulosin1938
1916 Chem. Abstr. 10 Index 3647/2 Thiazolidine (tetrahydrothiazole).
1945 Science 21 Dec. 628/2 Penicilloic acids are undoubtedly thiazolidines.
1949 E. Chain in H. W. Florey et al. Antibiotics II. xxii. 823 Penicillamine and its esters react readily with aldehydes or ketones to form thiazolidines.
1951 A. Grollman Pharmacol. & Therapeutics xxii. 443 Penicillin is a monocarboxylic acid with β-lactam and thiazolidine rings attached through a CONH linkage to a prosthetic group.
1979 Nature 25 Oct. 716/2 The chemical assay based on the behaviour of the fused thiazolidine-β-lactam ring consistently gave higher results than the bioassay which required the full penicillin molecule for biological activity.
This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018).
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