单词 | thalassaemia intermedia |
释义 | > as lemmasthalassaemia intermedia A hereditary hæmolytic anæmia common in malarious (or formerly malarious) areas and caused by the faulty synthesis of part of the hæmoglobin molecule, with symptoms that depend on the part of the molecule affected and on whether the individual is homozygous or heterozygous for the gene concerned; so thalassaemia major, thalassaemia intermedia, thalassaemia minor. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > deficiency of red cells > anaemia > types of ischemy1855 pernicious anaemia1874 ischaemia1878 Addison's anaemia1886 Addisonian pernicious anaemia1894 favism1903 Addisonian anaemia1904 hypoplastic anaemia1906 sickle cell anaemia1922 sicklemia1932 thalassaemia1932 Cooley's anaemia1934 Mediterranean disease1936 target cell anaemia1938 1932 G. H. Whipple & W. L. Bradford in Amer. Jrnl. Dis. Children 44 364 We do not like the term ‘erythroblastic anemia’... The disease is limited almost wholly to Italians, Greeks and Syrians, i.e., to the people originating about the Mediterranean Sea. For this reason the term ‘thalassemia’..may have an appeal. 1936 G. H. Whipple & W. L. Bradford in Jrnl. Pediatrics 9 279 (heading) Mediterranean disease—thalassemia (erythroblastic anemia of Cooley). 1944 J. V. Neel & W. N. Valentine in Arch. Internal Med. 74 196/2 It is suggested, on the basis of the pathologic and genetic evidence, that the full-blown disease be designated ‘thalassemia major’ and the milder carrier state ‘thalassemia minor’. 1954 K. Singer et al. in Blood IX. 1039 We have found the following simple classification very useful; it is based on the alterations of the red cell and hemoglobin levels: 1. Thalassemia major (Cooley's anemia): very severe microcytic hemolytic anemia. 2. Thalassemia intermedia, characterized by a less severe, but still marked anemia. 3. Thalassemia minor: mild anemia. 1962 Lancet 12 May 1006/2 As the hæmoglobinopathies grow in importance, a monograph taking stock of what we know of thalassæmia is welcome. 1972 D. E. Comings in W. J. Williams et al. Hematology xxxi. 332/2 Although the total number of individuals with thalassemia intermedia is relatively small.., it constitutes a clinically important group, since its relatively benign course (compared to thalassemia major) allows affected individuals to live to adulthood. 1973 B. J. Williams Evol. & Human Origins iv. 61/2 Osteoporosis occurs even with thalassemia minor. 1978 Jrnl. Royal Soc. Med. 71 465/1 The hepatic cirrhosis of thalassaemia major. 1979 Brit. Med. Jrnl. 17 Nov. 1298/2 The 26-year-old Chinese with beta-thalassaemia who had been transfused with 404 units of blood in his lifetime. His total body iron was so high that it triggered the alarm at an airport security checkpoint. 1982 New Scientist 21 Jan. 164/1 Red blood cells in people with thalassæmia cannot carry oxygen well enough, and patients survive only with regular blood transfusions. < as lemmas |
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