thalassaemian.
/θaləˈsiːmɪə/ Pathology.
A hereditary hæmolytic anæmia common in malarious (or formerly malarious) areas and caused by the faulty synthesis of part of the hæmoglobin molecule, with symptoms that depend on the part of the molecule affected and on whether the individual is homozygous or heterozygous for the gene concerned; so thalassaemia major, thalassaemia intermedia, thalassaemia minor.
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the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > deficiency of red cells > anaemia > types of
ischemy1855
pernicious anaemia1874
ischaemia1878
Addison's anaemia1886
Addisonian pernicious anaemia1894
favism1903
Addisonian anaemia1904
hypoplastic anaemia1906
sickle cell anaemia1922
sicklemia1932
thalassaemia1932
Cooley's anaemia1934
Mediterranean disease1936
target cell anaemia1938
1932 G. H. Whipple & W. L. Bradford in Amer. Jrnl. Dis. Children 44 364 We do not like the term ‘erythroblastic anemia’... The disease is limited almost wholly to Italians, Greeks and Syrians, i.e., to the people originating about the Mediterranean Sea. For this reason the term ‘thalassemia’..may have an appeal.
1936 G. H. Whipple & W. L. Bradford in Jrnl. Pediatrics 9 279 (heading) Mediterranean disease—thalassemia (erythroblastic anemia of Cooley).
1944 J. V. Neel & W. N. Valentine in Arch. Internal Med. 74 196/2 It is suggested, on the basis of the pathologic and genetic evidence, that the full-blown disease be designated ‘thalassemia major’ and the milder carrier state ‘thalassemia minor’.
1954 K. Singer et al. in Blood IX. 1039 We have found the following simple classification very useful; it is based on the alterations of the red cell and hemoglobin levels: 1. Thalassemia major (Cooley's anemia): very severe microcytic hemolytic anemia. 2. Thalassemia intermedia, characterized by a less severe, but still marked anemia. 3. Thalassemia minor: mild anemia.
1962 Lancet 12 May 1006/2 As the hæmoglobinopathies grow in importance, a monograph taking stock of what we know of thalassæmia is welcome.
1972 D. E. Comings in W. J. Williams et al. Hematology xxxi. 332/2 Although the total number of individuals with thalassemia intermedia is relatively small.., it constitutes a clinically important group, since its relatively benign course (compared to thalassemia major) allows affected individuals to live to adulthood.
1973 B. J. Williams Evol. & Human Origins iv. 61/2 Osteoporosis occurs even with thalassemia minor.
1978 Jrnl. Royal Soc. Med. 71 465/1 The hepatic cirrhosis of thalassaemia major.
1979 Brit. Med. Jrnl. 17 Nov. 1298/2 The 26-year-old Chinese with beta-thalassaemia who had been transfused with 404 units of blood in his lifetime. His total body iron was so high that it triggered the alarm at an airport security checkpoint.
1982 New Scientist 21 Jan. 164/1 Red blood cells in people with thalassæmia cannot carry oxygen well enough, and patients survive only with regular blood transfusions.
Derivatives
thalaˈssaemic n. a person with thalassæmia.
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the world > health and disease > ill health > a disease > disorders of internal organs > disorders of blood > [noun] > deficiency of red cells > anaemia > types of > person
sickler1932
thalassaemic1974
1974 Nature 8 Feb. 380/1 The δβ-thalassaemics were Sicilian and have been previously reported.
1979 Nature 15 Nov. 317/2 In one study, the incidence of HbF Sardinia in β-thalassaemics in Italy was 90%, compared with only 40% in normal Italians.
This entry has not yet been fully updated (first published 1986; most recently modified version published online December 2020).
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n.1932