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单词 taxane
释义

taxanen.

Brit. /ˈtakseɪn/, U.S. /ˈtækˌseɪn/
Origin: A borrowing from Latin, combined with an English element. Etymons: Latin Taxus , -ane suffix2.
Etymology: < scientific Latin Taxus, genus name ( < classical Latin taxus yew: see taxaceous adj.) + -ane suffix2.
Chemistry.
Any of a class of tricyclic terpenoid compounds isolated from certain trees and shrubs of the genus Taxus (the yews), or prepared synthetically; (also) a hydrocarbon having the C20 molecular skeleton present in these compounds.
ΚΠ
1964 B. Lythgoe et al. in Proc. Chem. Soc. 301/2 These constituents belong to a new type of diterpenoid, and since undoubtedly other compounds having the same skeleton exist in the plant, we suggest the name ‘Taxane’ for the nucleus.
1971 Ann. Rep. Delegates Sci. Area Univ. Oxf. 29 The isolation of seven new taxane derivatives from the heartwood of yew.
1994 Nature 17 Feb. 593/1 Its [sc. taxol's] attraction to pharmacologists was its unique structure, a complex diterpenoid containing the taxane ring system and a rare four-membered oxetane ring and ester side chain, that suggested the possibility of a new mechanism for an anti-tumour drug.
2000 New Scientist 13 May 7/3 Theryte..describes a test to determine which chemotherapy agent is best for treating a particular tumour: chemotherapy with cis-platinum or taxanes such as taxol.
This is a new entry (OED Third Edition, March 2005; most recently modified version published online March 2022).
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n.1964
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