tamoxifenn.

/təˈmɒksɪfɛn/

Etymology: < t (perhaps < trans- prefix) + am- (in amine n.) + oxy- comb. form¹ + phen- (in phenol n.), with alteration of y and ph.

Pharmacology.

An œstrogen antagonist, (CH₃)₂N(CH₂)₂·O·C₆H₄·(C₆H₅)C:C(C₆H₅)·CH₂CH₃, used to treat breast cancer and infertility in women.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia

amethopterin1948

Myleran1952

Laetrile1953

thioguanine1953

thioTEPA1953

mercaptopurine1954

methotrexate1955

busulfan1956

chlorambucil1956

cyclophosphamide1960

vinblastine1962

vincristine1962

levamisole1969

vinca alkaloid1970

doxorubicin1971

tamoxifen1972

Airol1974

trastuzumab1997

thiotepa-

1972 Approved Names 1970 (Brit. Pharmacopœia Comm.) Suppl. iv. 6 Tamoxifen.

1972 Clin. Endocrinol. I. 275 A derivative of triphenylethylene was examined by Harper & Walpole (1967a,b) for its anti-oestrogenic activity in rats. This compound..was subsequently named tamoxifen.

1980 Brit. Med. Jrnl. 29 Nov. 1459/1 Lung metastases then enlarged and tamoxifen was substituted but discontinued after only two months because of progressive disease.

This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018).

单词	tamoxifen
释义	tamoxifenn. /təˈmɒksɪfɛn/ Etymology: < t (perhaps < trans- prefix) + am- (in amine n.) + oxy- comb. form¹ + phen- (in phenol n.), with alteration of y and ph. Pharmacology. An œstrogen antagonist, (CH₃)₂N(CH₂)₂·O·C₆H₄·(C₆H₅)C:C(C₆H₅)·CH₂CH₃, used to treat breast cancer and infertility in women. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for cancer or leukemia amethopterin1948 Myleran1952 Laetrile1953 thioguanine1953 thioTEPA1953 mercaptopurine1954 methotrexate1955 busulfan1956 chlorambucil1956 cyclophosphamide1960 vinblastine1962 vincristine1962 levamisole1969 vinca alkaloid1970 doxorubicin1971 tamoxifen1972 Airol1974 trastuzumab1997 thiotepa- 1972 Approved Names 1970 (Brit. Pharmacopœia Comm.) Suppl. iv. 6 Tamoxifen. 1972 Clin. Endocrinol. I. 275 A derivative of triphenylethylene was examined by Harper & Walpole (1967a,b) for its anti-oestrogenic activity in rats. This compound..was subsequently named tamoxifen. 1980 Brit. Med. Jrnl. 29 Nov. 1459/1 Lung metastases then enlarged and tamoxifen was substituted but discontinued after only two months because of progressive disease. This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018). < n.1972
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