| 单词 | synthalin b |
| 释义 | > as lemmassynthalin B A synthetic but toxic aliphatic diguanidine which has the hypoglycæmic effect of insulin when taken orally; decamethylene-diguanidine, H2N·C(NH)·NH·(CH2)10·NH·C(NH)·NH2; also called synthalin A; synthalin B, an analogous compound in which —(CH2)10— is replaced by —(CH2)12—. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for diabetes synthalin1927 protamine insulin1935 protamine zinc insulin1935 Ultralente1953 sulphonylurea1956 tolbutamide1956 phenformin1959 acetohexamide1961 metformin1961 tolazamide1963 1927 Chem. Abstr. 21 772 To produce a molecule of min. toxicity and max. insulin activity, further changes were made in the mol...which resulted finally in a deriv. that is called Synthalin. 1936 Hill & Howitt Insulin ix. 190 The decided differences between the action of both synthalin and synthalin-B and insulin render even these substances doubtful as effective substitutes for the hormone. 1952 Morton & Hoggarth in E. H. Rodd Chem. Carbon Compounds I b. xiv. 931 This compound depresses the concentration of blood sugar, a property which is even more marked in certain diguanidines such as ‘Synthalin’. 1961 Lancet 30 Sept. 776/1 Synthalin with two guanidines joined by a chain of methyl groups is a diguanidine. In phenformin the two guanidines coalesce..and it is a diguanide (or biguanide). 1980 J. Crossland Lewis's Pharmacol. (ed. 5) lvi. 878/1 In the early 1920's..it was found that a number of aliphatic diguanidines such as the Synthalins A and B..produced hypoglycaemia in man. < as lemmas |
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