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1904 U.S. Geol. Surv., Monogr. XLVII. 205 Sulphation is the union of sulphuric acid with base or the substitution of sulphuric acid for another combined acid.

1957 New Biol. 24 52 There is an informed opinion which asserts that sulphation is not necessary for metachromasia and that mucopolysaccharides without sulphur are also metachromatic.

1971 J. M. Tanner et al. in Arch. Dis. Childhood XLVI. 761/2 A few patients with short stature have the ability to secrete immunoreactive GH..; but their GH fails to stimulate the production of somatomedin, a substance found in the blood, and previously named ‘sulphation factor’.

1972 W. H. Daughaday et al. in Nature 14 Jan. 107/2 After consideration of many alternatives to the operational terms ‘sulphation factor’ or ‘thymidine factor’, we propose the more general term, ‘somatomedin’; the prefix, ‘somato’, connotes both a hormonal relationship to somatotropin and, also, to the soma which is the target tissue of this agent. ‘Medin’ is included in the name to indicate that it is an intermediary in somatotropin action.

1975 Nature 24 Jan. 269/2 Somatomedin, previously known as ‘sulphation factor’,..stimulates the incorporation of ³⁵SO₄ into costal cartilage.

1977 Lancet 22 Jan. 168/1 The mammary gland itself may be the site of sulphation [of vitamin D].