subtilisinn.
/sʌbˈtɪlɪsɪn/, U.S. /səbˈtɪlɪs(ə)n/ Biochemistry.
Any of a group of proteolytic enzymes originally isolated from the soil-borne bacterium Bacillus subtilis and used in detergents, processed foods, etc., and in research.Subtilisins are produced by numerous species of Bacillus; those used commercially include B. licheniformis and B. amyloliquefaciens.
ΚΠ
1953 A. V. Güntelberg & M. Ottesen in Compt. Rend. des Travaux du Laboratoire Carlsberg: Ser. Chim. XXIX. 47 Since..the B. subtilis proteinase appears to be a rather well defined enzyme..we feel that it will be appropriate to give it a name, and we propose to call it ‘subtilisin’.
1968 A. White et al. Princ. Biochem. (ed. 4) xii. 255 This is indicated by the finding that the subtilisins, proteolytic enzymes of Bacillus subtilis of different genetic origin, possess entirely different amino acid sequences.
1988 L. Stryer Biochem. (ed. 3) viii. 178 Subtilisin..is quite undiscriminating about the nature of the side chains adjacent to the peptide bond to be cleaved.
2003 Amer. Scientist Nov. 531 (caption) Subtilisin is a protein-degrading enzyme used in laundry detergent and the most highly engineered enzyme in existence.
This entry has been updated (OED Third Edition, June 2012; most recently modified version published online March 2022).
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