acetoaceticadj.
/əˌsiːtəʊəˈsiːtɪk/, /ˌasᵻtəʊəˈsiːtɪk/, U.S. /ˌæsəˌtoʊəˈsidɪk/, /əˌsidoʊəˈsidɪk/ Chemistry.
1. acetoacetic ether n. disused = acetoacetic ester n.
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1880 Jrnl. Chem. Soc. 38 625 In the case of the homologous acetoacetic ethers, the reactions are parallel at all points.
1908 Science 15 May 770/1 Whether a 1,3 dicarbonyl derivative, like acetoacetic ether, is a ketone..or an alcohol.
2. acetoacetic acid n. a weak acid which is an intermediate in the catabolism of fatty acids and amino acids and is one of the ketone bodies produced in greater quantity in conditions of impaired carbohydrate metabolism, such as diabetes mellitus and starvation.Acetoacetic acid, a viscous, unstable liquid when pure, is a beta-keto acid, systematic name: 3-oxobutanoic acid; CH3COCH2COOH.
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1880 Jrnl. Chem. Soc. 38 625 The author has studied the ethyl salts of methyl-, ethyl-, propyl-, isopropyl-, isobutyl-, and methylethyl-acetoacetic acid.]
1881 H. Watts Dict. Chem. VIII. 1918 Tetric acid and its homologues..are formed by the successive action of bromine and alcoholic potash on the ethylic ethers of aceto-acetic acid and its homologues.
1913 Jrnl. Biol. Chem. 13 513 Proline, when added to blood used for perfusing a surviving dog's liver, leads to no increase in the normal formation of acetoacetic acid.
1956 Nature 24 Mar. 545/1 The formation of large amounts of acetoacetic acid CH3—CO—CH2—COOH.
1992 Science 30 Oct. 767/2 Diabetic ketoacidosis. The hallmarks of this condition are severe hyperglycemia coupled with marked elevation in the circulating concentrations of acetoacetic and β-hydroxybutyric acids.
3. acetoacetic ester n. a colourless liquid, the ethyl ester of acetoacetic acid, used as a solvent and in organic synthesis; (also) any ester of this acid.Systematic name: ethyl 3-oxobutanoate; CH3COCH2COOC2H5. Also called ethyl acetylacetate.
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1894 P. H. Seymour (title) Bibliography of aceto acetic ester and its derivatives.
1900 Jrnl. Physical Chem. 4 48 This is a preliminary paper on benzylidene acetoacetic ester.
1903 A. J. Walker & O. E. Mott tr. A. F. Holleman Text-bk. Org. Chem. I. 291 Acetoacetic acid..is not of much importance, but its ethyl ester, acetoacetic ester, is a very interesting compound.
1957 Technology Aug. 226/2 Another [chapter] on..synthetic reagents includes..acetoacetic and malonic esters.
1984 Science 30 Nov. 1091/3 Acetoacetic ester binds reversibly to ε-amino groups of lysine residues.
2000 C. A. Russell in F. L. Holmes & T. H. Levere Instruments & Exper. Hist. Chem. xii. 314 A reflux condenser..has been employed for simple reactions, such as..preparation of acetoacetic ester.
This entry has been updated (OED Third Edition, September 2009; most recently modified version published online December 2021).
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adj.1880