acetaniliden.
/ˌasᵻˈtanᵻlʌɪd/, U.S. /ˌæsəˈtænəˌlaɪd/ Chemistry and Pharmacology.
A white flaky solid used in organic synthesis, as an inhibitor of hydrogen peroxide, and (formerly) as an antiseptic, analgesic, and antipyretic.Systematic name: N-phenylacetamide; CH3CO·NH·C6H5.
ΚΠ
1857 H. Watts tr. L. Gmelin Hand-bk. Chem. XI. 314 The solution on cooling deposits the acetanilide in splendid laminæ.
1869 H. E. Roscoe Lessons Elem. Chem. (new ed.) xxxix. 383 This [sc. aniline acetate] on heating loses a molecule of water, yielding an amide called acetanilide.
1897 Trans. Amer. Pediatric Soc. 9 41 I have collected several cases of acetanilide poisoning in children where the drug was used externally as an antiseptic.
1909 E. I. Lewis Elements Org. Chem. xxi. 165 Like other primary amines, aniline reacts with acetyl chloride to form an acetyl compound. This is called Acetanilide. It is used under the name of Antifebrine for lowering the temperature in cases of fever.
1956 Lancet 24 Mar. 339/1 Acetanilide is a dangerous drug because the body de-acetylates part of it into aniline.
2003 K. M. Dunn Caveman Chem. xxvi. 338 The reaction of aniline with acetic anhydride to produce acetic acid and acetanilide.
This entry has been updated (OED Third Edition, September 2009; most recently modified version published online December 2021).
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