spironolactonen.
/ˌspʌɪərənəʊˈlaktəʊn/ Pharmacology.
A steroid spirolactone derivative, C24H32O4S, which is an aldosterone antagonist, increasing sodium excretion, and is used esp. in the treatment of œdema and hypertension associated with hyperaldosteronism.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for blood-pressure disorders > biological or synthetic
spironolactone1960
minoxidil1970
saralasin1974
1960 Austral. Ann. Med. IX. 188/1 In the present paper we describe the use of a similar drug, spironolactone (‘SC 9420’, ‘Aldactone’, Searle).
1961 Lancet 2 Sept. 528/2 Spironolactone 100 mg. four times daily definitely improved six out of seven myasthenic patients.
1974 R. M. Kirk et al. Surgery vii. 146 Treatment with diuretics or spironolactone, and dietary salt restriction, help to reduce the accumulation of fluid.
1977 Lancet 17 Sept. 600/2 Spironolactone relieved muscle fatigue in paramyotonia congenita—an effect possibly mediated by the accompanying hyperkalæmia.
This entry has not yet been fully updated (first published 1986; most recently modified version published online March 2019).
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n.1960