spirolactonen.

/spʌɪrəʊˈlaktəʊn/

Etymology: < spiro- comb. form 2 + lactone n. 2.

Chemistry and Pharmacology.

Any spirane in which one of the rings is a lactone; spec. any of the series of steroid derivatives to which spironolactone belongs.

ΘΚΠ

the world > matter > chemistry > organic chemistry > organic compounds > [noun] > cyclic compounds > bicyclic compounds

purine1898

halowax1922

spirolactone1958

1958 Canad. Med. Assoc. Jrnl. 79 883/1 The administration of Spirolactone results in a persistent and significant increase in sodium excretion.

1959 Jrnl. Org. Chem. 24 743/1 The spirolactone side chain was built onto a steriod nucleus containing an aromatic A ring.

1961 Lancet 16 Sept. 618/2 With the development of the 17-spirolactones, which are aldosterone antagonists, a new method has become available for investigating possible cases of primary aldosteronism.

1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. xi. 10/1 The main reason for believing that spirolactones are aldosterone antagonists is that they reverse all the renal effects of aldosterone.

This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018).

单词	spirolactone
释义	spirolactonen. /spʌɪrəʊˈlaktəʊn/ Etymology: < spiro- comb. form 2 + lactone n. 2. Chemistry and Pharmacology. Any spirane in which one of the rings is a lactone; spec. any of the series of steroid derivatives to which spironolactone belongs. ΘΚΠ the world > matter > chemistry > organic chemistry > organic compounds > [noun] > cyclic compounds > bicyclic compounds purine1898 halowax1922 spirolactone1958 1958 Canad. Med. Assoc. Jrnl. 79 883/1 The administration of Spirolactone results in a persistent and significant increase in sodium excretion. 1959 Jrnl. Org. Chem. 24 743/1 The spirolactone side chain was built onto a steriod nucleus containing an aromatic A ring. 1961 Lancet 16 Sept. 618/2 With the development of the 17-spirolactones, which are aldosterone antagonists, a new method has become available for investigating possible cases of primary aldosteronism. 1970 R. Passmore & J. S. Robson Compan. Med. Stud. II. xi. 10/1 The main reason for believing that spirolactones are aldosterone antagonists is that they reverse all the renal effects of aldosterone. This entry has not yet been fully updated (first published 1986; most recently modified version published online June 2018). < n.1958
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