| 单词 | senile plaque |
| 释义 | > as lemmassenile plaque d. Pathology. A circumscribed area of degeneration in the cerebral cortex, containing amyloid and neural processes, seen esp. in Alzheimer's disease. Also called neuritic plaque, senile plaque. ΚΠ 1912 Jrnl. Nerv. & Mental Dis. 39 555 Formerly these neurofibril alterations in combination with plaques were considered of great diagnostic significance for the mental disorder under consideration [sc. Alzheimer's disease]. 1955 H. H. Merritt Textbk. Neurol. vi. 417 There is a diffuse loss of cells in all layers of the cortex, secondary gliosis, argentophile plaques (Alzheimer plaques) and neurofibrillar degeneration. 1967 Brain 90 864 Silver impregnation..showed many cortical plaques and neurofibrillary tangles of Alzheimer's disease. 1996 Pulse 20 Apr. 38/3 Once we know which proteins are associated with the production and accumulation of plaques containing beta-amyloid protein, drug therapy could be targeted to modify their expression. < as lemmas |
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