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1814 S. T. Coleridge Let. 19 May (1959) III. 494 You were so good as to procure..a Clyster Machine of most convenient construction for self-injection.

1895 L. S. Beale On Slight Ailments 235 Every now and then death occurs from an overdose [of morphine], in consequence of patients who have contracted this habit of self-injection losing all control over themselves.

1937 Brit. Med. Jrnl. 10 July 22/2 It fell to the practitioner to instruct him in the self-injection of insulin or liver extract.

2016 Times (Nexis) 13 Dec. 18 In October the health board announced that it had agreed in principle to open self-injection rooms, where users would also be able to buy medical-grade heroin as a safer alternative to street drugs.