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单词 second messenger
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second messenger
second messenger n. Physiology a substance whose release within a cell is promoted by a hormone or ‘first messenger’, and which brings about a response by the cell.
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second messenger1965
1965 E. W. Sutherland et al. in Rec. Progress Hormone Res. 21 640 The hormone (the first messenger) interacts with a component of the cell membrane to initiate increased accumulation of a mediator (the second messenger), which then acts upon components of the effector cell.
1968 Circulation 37 300/1 Although cyclic AMP stands as the only well-established second messenger to date, data supporting such a role for cyclic GMP have been obtained.
1979 Sci. Amer. Sept. 127/1 The methylxanthine drugs, such as caffeine and theophylline, are thought to exert their effects by acting through the second-messenger system.
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