reserpinen.

Brit.

/ˈrɛsəpiːn/,

/ˈrɛsəpɪn/,

/rᵻˈsəːpiːn/, U.S.

/rəˈsərpən/,

/riˈsərpən/,

/rəˈsərˌpin/,

/riˈsərˌpin/,

/ˈrɛsərˌpin/,

/ˈrɛsərpən/

Origin: A borrowing from German. Etymon: German Reserpin.

Etymology: < German Reserpin (J. M. Müller et al. 1952, in Experientia 8 338) < re- (representing rauwolfia n.) + serp- (in scientific Latin serpentina , specific epithet (feminine of classical Latin serpentīnus serpentine adj.)) + -in -ine suffix⁵.

Pharmacology.

An alkaloid obtained from the roots of the plant Rauvolfia serpentina and other members of the genus Rauvolfia (family Apocynaceae), which reduces the concentration of catecholamines and serotonin in neural tissues and has been used as a sedative and antihypertensive drug.Formula: C₃₃H₄₀N₂O₉.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for blood-pressure disorders > plant-derived

rutin1845

veratridine1907

rauwolfia1950

Raudixin1953

Rauwiloid1953

reserpine1953

the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > sedative > plant-derived

hemlocka700

labdanuma1400

laudanumc1602

ladanum1638

hyoscyamus1799

hyoscyamia1821

thridace1829

hyoscyamine1858

scopolamine1892

reserpine1953

1953 Experientia 9 331 (title) On the constitution of reserpine.

1958 Observer 30 Nov. 12/4 New drugs such as chlorpromazine and reserpine make the minds of the mentally ill more accessible.

1966 New Scientist 24 Nov. 430/3 Reserpine interferes with the retention, mainly in the hypothalamus.., of a number of amines.

1973 Sci. Amer. Sept. 121/1 Once widely used, reserpine has been replaced by the phenothiazines because of the greater frequency of reserpine's serious side effects.

1991 New Scientist 17 Aug. 38/2 Doctors have treated hypertension with reserpine for nearly 30 years in the West, but the shrub that produces it has been used in herbal tranquillisers for millennia.

2000 J. Mann Murder, Magic, & Med. (rev. ed.) iv. 202 A lot of the treatment still relies on the use of tranquillizers, and one natural plant drug, reserpine, has proved of great value both for therapy and as an aid to understanding neurological disorders.

Derivatives

reˈserpinized adj. treated with reserpine.

ΘΚΠ

the world > health and disease > healing > medical treatment > treatment by medicine or drug > [adjective] > treated with specific drugs

citrated1757

oxalated1893

mercurialized1897

insulinized1928

strychninized1938

heparinized1940

reserpinized1955

1955 Ann. N.Y. Acad. Sci. 61 52 It is perfectly possible that, with higher shock intensities, reserpinized animals would also exhibit avoidance behavior.

1966 Progress Cardiovascular Res. 8 560 In reserpinized patients exhibiting atrial fibrillation, marked bradycardia..and abnormal responses to carotid massage occurred.

1996 European Jrnl. Pharmacol. 317 29 In mice, this compound stimulated cage climbing and locomotor activity in reserpinized animals.

reˌserpiniˈzation n. treatment with reserpine; the condition resulting from this.

ΘΚΠ

the world > health and disease > healing > medical treatment > treatment by medicine or drug > [noun] > treatment with specific substances

mercurialization1825

cinchonization1875

helleborism1883

cocainization1887

tuberculinization1892

gold therapy1894

strychninization1898

venomization1905

strychnization1916

heparinization1956

reserpinization1959

1959 S. W. Hoobler & P. Blaquier in J. H. Moyer Hypertension 385 After six to eight weeks of initial ‘reserpinization’..it is possible to maintain therapeutic effects with doses of 0.125 to 0.25 mg. daily.

1973 Nature 13 Apr. 463/1 In the absence of endogenous catecholamines (that is reserpinization) the transient contractile tension response to the ionophore was attenuated.

1998 Histochem. Jrnl. 30 263 Ten days after reserpinization, followed by repeated 5-hydroxytryptamine treatment, the enzyme activity was detectable.

This entry has been updated (OED Third Edition, March 2010; most recently modified version published online March 2022).

单词	reserpine
释义	reserpinen. Brit. /ˈrɛsəpiːn/, /ˈrɛsəpɪn/, /rᵻˈsəːpiːn/, U.S. /rəˈsərpən/, /riˈsərpən/, /rəˈsərˌpin/, /riˈsərˌpin/, /ˈrɛsərˌpin/, /ˈrɛsərpən/ Origin: A borrowing from German. Etymon: German Reserpin. Etymology: < German Reserpin (J. M. Müller et al. 1952, in Experientia 8 338) < re- (representing rauwolfia n.) + serp- (in scientific Latin serpentina , specific epithet (feminine of classical Latin serpentīnus serpentine adj.)) + -in -ine suffix⁵. Pharmacology. An alkaloid obtained from the roots of the plant Rauvolfia serpentina and other members of the genus Rauvolfia (family Apocynaceae), which reduces the concentration of catecholamines and serotonin in neural tissues and has been used as a sedative and antihypertensive drug.Formula: C₃₃H₄₀N₂O₉. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for blood-pressure disorders > plant-derived rutin1845 veratridine1907 rauwolfia1950 Raudixin1953 Rauwiloid1953 reserpine1953 the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > sedative > plant-derived hemlocka700 labdanuma1400 laudanumc1602 ladanum1638 hyoscyamus1799 hyoscyamia1821 thridace1829 hyoscyamine1858 scopolamine1892 reserpine1953 1953 Experientia 9 331 (title) On the constitution of reserpine. 1958 Observer 30 Nov. 12/4 New drugs such as chlorpromazine and reserpine make the minds of the mentally ill more accessible. 1966 New Scientist 24 Nov. 430/3 Reserpine interferes with the retention, mainly in the hypothalamus.., of a number of amines. 1973 Sci. Amer. Sept. 121/1 Once widely used, reserpine has been replaced by the phenothiazines because of the greater frequency of reserpine's serious side effects. 1991 New Scientist 17 Aug. 38/2 Doctors have treated hypertension with reserpine for nearly 30 years in the West, but the shrub that produces it has been used in herbal tranquillisers for millennia. 2000 J. Mann Murder, Magic, & Med. (rev. ed.) iv. 202 A lot of the treatment still relies on the use of tranquillizers, and one natural plant drug, reserpine, has proved of great value both for therapy and as an aid to understanding neurological disorders. Derivatives reˈserpinized adj. treated with reserpine. ΘΚΠ the world > health and disease > healing > medical treatment > treatment by medicine or drug > [adjective] > treated with specific drugs citrated1757 oxalated1893 mercurialized1897 insulinized1928 strychninized1938 heparinized1940 reserpinized1955 1955 Ann. N.Y. Acad. Sci. 61 52 It is perfectly possible that, with higher shock intensities, reserpinized animals would also exhibit avoidance behavior. 1966 Progress Cardiovascular Res. 8 560 In reserpinized patients exhibiting atrial fibrillation, marked bradycardia..and abnormal responses to carotid massage occurred. 1996 European Jrnl. Pharmacol. 317 29 In mice, this compound stimulated cage climbing and locomotor activity in reserpinized animals. reˌserpiniˈzation n. treatment with reserpine; the condition resulting from this. ΘΚΠ the world > health and disease > healing > medical treatment > treatment by medicine or drug > [noun] > treatment with specific substances mercurialization1825 cinchonization1875 helleborism1883 cocainization1887 tuberculinization1892 gold therapy1894 strychninization1898 venomization1905 strychnization1916 heparinization1956 reserpinization1959 1959 S. W. Hoobler & P. Blaquier in J. H. Moyer Hypertension 385 After six to eight weeks of initial ‘reserpinization’..it is possible to maintain therapeutic effects with doses of 0.125 to 0.25 mg. daily. 1973 Nature 13 Apr. 463/1 In the absence of endogenous catecholamines (that is reserpinization) the transient contractile tension response to the ionophore was attenuated. 1998 Histochem. Jrnl. 30 263 Ten days after reserpinization, followed by repeated 5-hydroxytryptamine treatment, the enzyme activity was detectable. This entry has been updated (OED Third Edition, March 2010; most recently modified version published online March 2022). < n.1953
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