renaturev.
/ˌriːˈneɪtʃə/, U.S. /riˈneɪtʃər/, /rəˈneɪtʃər/ Chiefly Biochemistry.
1. transitive. To restore the nature or properties of (a substance that has been denatured, esp. a protein or nucleic acid). Chiefly in passive.
ΘΚΠ
the world > matter > chemistry > chemical reactions or processes > subject to chemical reactions or processes [verb (transitive)] > subject to named chemical reaction or process > subject to renaturation
renature1907
1907 Harper's Mag. Aug. 464/1 In the skyscrapers of New York and in the ranches of Kansas there will be moonlighting plants renaturing for beverage purposes the denatured material.
1946 Nature 30 Nov. 768/2 Some fairly close system of supervision by the international authority will be essential to ensure that the denatured material..is not being ‘renatured’ so as to make it suitable for use in a bomb.
1977 Sci. Amer. (U.K. ed.) Apr. 44/2 After cooling and the removal of the detergent the interferon recovered its original biological activity: it was renatured.
2005 Proc. National Acad. Sci. U.S.A 102 7157/1 Ribonuclease A can be reversibly denatured and renatured in solution.
2. intransitive. To undergo renaturation.
ΘΚΠ
the world > matter > chemistry > chemical reactions or processes > undergo chemical reactions or processes [verb (intransitive)] > undergo chemical reactions or processes (named) > undergo renaturation
renature1960
1960 Proc. National Acad. Sci. U.S.A. 46 474 Molecules..show a strong preference for renaturing only with members of their homologous species.
1988 P. W. Kuchel et al. Schaum's Outl. Theory & Probl. Biochem. vii. 186 Viral DNA therefore would renature faster than bacterial DNA.
2003 Plant Cell 15 2126/2 After electrophoresis, resolved proteins were allowed to renature and then were assayed.
Derivatives
reˈnaturable adj. capable of being renatured.
ΚΠ
1961 Proc. National Acad. Sci. U.S.A. 47 662 A readily renaturable molecule retaining a sufficient number of hydrogen-bonded points of contact to hold the two strands together in one or more regions.
1997 Jrnl. Cellular Physiol. 172 94 Members of a family of ‘renaturable kinases’ are rapidly activated in neutrophils in response to diverse physiological agonists.
reˈnaturing n.
ΚΠ
1909 Denatured Alcohol at Home & Abroad 8 The discovery of the renaturing and improper use of denatured alcohol.
1955 Bull. Atomic Scientists Jan. 12/1 If reconversion of the denatured nuclear explosives is not a protracted process, the threat of seizure, renaturing, and atomic rearmament would remain indefinitely.
2006 W. Luttmann et al. Immunol. i. 27 The following renaturing of the recombinant proteins is difficult and must be tested empirically for each protein.
This entry has been updated (OED Third Edition, December 2009; most recently modified version published online March 2022).
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