reaginn.

1911 R. W. Matson tr. A. Wolff-Eisner Clin. Immunity & Sero-diagnosis iii. 33 To avoid errors, it is..best to use the term ‘reactive substances’ (reagins) rather than ‘antibodies’, since the latter implies a neutralization in the sense of an antitoxin.

1913 S. Afr. Jrnl. Sci. 9 196 The use of the expression ‘antibodies’ is now very widespread (although the term ‘Reagins’ has also been suggested).

1915 J. E. R. McDonagh Biol. & Treatm. Venereal Dis. x. 71 Owing..to the fact that a positive Wassermann reaction may be obtained in conditions other than syphilitic ones, the reaction ceases to be a specific reaction. Therefore the third factor ought not to be called an antibody, since it is in no wise specific, hence it is best called reacting substance, or Reagin.

1937 H. Eagle Lab. Diagnosis Syphilis i. 24 There is reason to believe that Wasserman's first theory was correct, and that the active component of syphilitic serum, so-called reagin, may well be an antibody to Spirochaeta pallida despite its reactivity with normal tissue lipoids.

1955 Albuquerque (New Mexico) Tribune 16 Nov. 19/2 But reagin can be present because of a number of diseases other than syphilis, Rosenblum said.

1976 A. E. Wilkinson in R. D. Catterall & C. S. Nicol Sexually Transmitted Dis. 215 Although the function of reagin is still uncertain, its level seems to be roughly related to the amount of tissue reaction by the host, rising rapidly with increasing numbers of treponemes in early syphilis and later falling as the number of organisms declines with developing immunity.

1990 Brain 113 1311 The rapid plasma reagin (RPR) test for syphilis was positive in the serum in 5 patients.

1925 A. F. Coca & E. F. Grove in Jrnl. Immunol. 10 448 It will be convenient to introduce here a term with which to designate the specifically reacting substances in the serum of atopic individuals... We would like to suggest the noncommittal term ‘atopic reagin’, adopting here a term already used to designate the reacting serum element responsible for the Wassermann reaction—the Wassermann reagin.

1952 Amer. Jrnl. Med. 13 762/1 The allergy hypothesis received some support from the observations..which indicated that an atopic reagin might be located or fixed in the colonic mucosa.

1977 Nature 16 June 618/1 Allergic diseases such as hay fever, extrinsic asthma, drug hypersensitivities and some forms of urticaria are mediated by allergen-specific antibodies of the IgE class, known also as reagins.

1993 Vet. Immunol. & Immunopathol. 37 83 The reagin was characterized as..possessing long term skin sensitizing activity.

1931 A. F. Coca Asthma & Hay Fever in Theory & Pract. I. xvii. 332 Bona fide reaginic reactions are indicative of past, present or potential sensitivities in the atopic individual.

1945 Vet. Rec. 57 339/2 (heading) Reaginic allergy in cattle.

1974 Kidney Internat. 5 296/2 Such observations suggested that reaginic (IgE) antibody-antigen immune complexes may have participated in the genesis of those cases of idiopathic-nephrotic syndrome.

1996 Transfusion Med. Rev. 10 297/1 These methods use a complex lipid antigen called cardiolipin to detect the nonspecific reaginic antibodies that develop in high titer in patients with active syphilis.