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单词 reading frame
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reading frame
reading frame n. Molecular Biology the way in which a sequence of nucleotides is grouped into a series of consecutive, non-overlapping triplets for transcription or translation; (also) a nucleotide sequence that starts with an initiation codon, continues as a series triplets that encode amino acids, and ends with a termination codon.
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1961 F. H. C. Crick et al. in Nature 30 Dec. 1229/2 If the code is made of triplets, any long sequence of bases can be read correctly in one way, but incorrectly (by starting at the wrong point) in two different ways, depending whether the ‘reading frame’ is shifted one place to the right or one place to the left.
1981 E. D. Hanson Understanding Evol. iv. 103 Shifts in the reading frame of codon triplets, like nucleotide substitutions, may or may not cause a detectable mutation.
2004 S. D. Smith in M. L. Rice & S. F. Warren Developmental Lang. Disorders xiii. 347 Mutations that are particularly disruptive..include insertions or deletions of DNA, which change the ‘reading frame’ of the codons so that the amino acid sequence that results is incorrect.
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