pyrazinamiden.
/ˌpɪrəˈzɪnəmʌɪd/, U.S. /ˌpɪrəˈzɪnəˌmaɪd/ Pharmacology.
An antibiotic used in the treatment of tuberculosis.Chemical name: pyrazine-2-carboxamide, CH=NCH=CHN=C—CONH2.
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the world > health and disease > healing > medicines or physic > medicines for specific purpose > preparations treating or preventing specific ailments > [noun] > for tuberculosis
Koch's tuberculin1890
tuberculin1891
tuberculocidin1891
tuberculocide1892
Sanocrysin1924
promizole1944
streptomycin1944
para-aminosalicylic acid1946
pyrazinamide1947
viomycin1950
Marsilid1952
thiacetazone1952
iproniazid1953
isoniazid1953
isonicotinic hydrazide1956
ethionamide1959
strep1959
rifampicin1966
rifampin1968
1945 Jrnl. Amer. Chem. Soc. 67 1713/2 The synthesis of four new pyrazine derivatives, 2-amino-3-carbomethoxypyrazine, 3-aminopyrazinamide, 3-acetamidopyrazinamide and 3-aminopyrazinenitrile, is described.]
1947 Chem. Rev. 40 339 The sodium salt of the intermediate carbamate could be isolated when the [Hofmann] reaction was carried out with pyrazinamide.
1974 R. M. Kirk et al. Surgery ii. 29/2 Ethionamide, pyrazinamide, viomyocin [sic] and capreomycin may be used in the treatment of tuberculosis.
2006 Internat. Jrnl. Tuberculosis & Lung Dis. 10 317 Pyrazinamide (PZA) is an effective sterilising drug in tuberculosis, but its mode of action is controversial.
This entry has been updated (OED Third Edition, December 2007; most recently modified version published online March 2022).
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n.1947