单词 | pyocyanase |
释义 | pyocyanasen. Medicine. Now historical. An antibiotic preparation, originally thought to be an enzyme, obtained from cultures of the bacterium Pseudomonas aeruginosa and formerly used to treat diphtheria and other infections. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > antibiotics > [noun] > other antibiotics pyocyanase1900 fumigatin1938 M and B1938 gramicidin1940 tyrocidine1940 tyrothricin1940 clavacin1942 fumigacin1942 streptothricin1942 aspergillic acid1943 aspergillin1943 clavatin1943 helvolic acid1943 streptomycin1944 subtilin1944 bacitracin1945 viridin1945 javanicin1946 nisin1947 nitrofurazone1947 polymyxin1947 aureomycin1948 chloramphenicol1949 clitocybin1949 neomycin1949 Terramycin1950 viomycin1950 cephalosporin1951 fumagillin1951 nigericin1951 achromycin1952 carbomycin1952 erythromycin1952 nystatin1952 oxytetracycline1952 tetracycline1952 chlortetracycline1953 nitrofurantoin1953 oligomycin1953 puromycin1953 bacteriocin1954 albomycin1955 spiramycin1955 valinomycin1955 amphotericin B1956 mitomycin1956 novobiocin1956 oleandomycin1956 paromomycin1956 vancomycin1956 kanamycin1957 macrolide1957 ristocetin1957 streptovaricin1957 ethionamide1959 rifamycin1959 strep1959 mithramycin1960 fucidin1961 virginiamycin1961 cephalothin1962 fusidic acid1962 nonactin1962 trimethoprim1962 daunomycin1963 lincomycin1963 anthracycline1964 cephaloridine1964 spectinomycin1964 doxycycline1966 rifampicin1966 minocycline1967 rifampin1968 Adriamycin1969 daunorubicin1969 ribostamycin1970 doxorubicin1971 tobramycin1971 milbemycin1975 fluoroquinolone1984 1900 Jrnl. Chem. Soc. 78 ii. 159 Thus pyocyanase, the enzyme of Bacillus pyocyaneus, destroys the deadly effect of the diphtheria toxin. 1908 Lancet 21 Mar. 899/1 If pyocyanase came in contact with leucocytes, their plasma was dissolved so that the granules and the nuclei only remained and these were..immobilised. 1949 H. W. Florey et al. Antibiotics I. i. 24 After 1914 the mention of pyocyanase for clinical use almost entirely disappeared from the literature. 1969 Listener 5 June 781/1 The experiments of Florey and Chain on pyocyanase..went to show that pyocyanase was a complicated mixture of substances, all equally poisonous to microbes and to mice. 1995 Amer. Jrnl. Med. 99 Suppl. 11s/2 This pyocyanase was actually tried with ‘moderate success’ in patients, but it was ultimately abandoned as unreliable and much too toxic by 1913. This entry has been updated (OED Third Edition, December 2007; most recently modified version published online March 2022). < |
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