单词 | pseudohypoparathyroidism |
释义 | pseudohypoparathyroidismn. Medicine. An inherited disorder in which the biochemical findings of hypoparathyroidism (hypocalcaemia and hyperphosphataemia) occur in the presence of a normal or elevated level of parathyroid hormone, frequently accompanied by skeletal and other abnormalities.The most common form of pseudohypoparathyroidism exhibits autosomal dominant inheritance and is caused by defects in the stimulatory guanine nucleotide-binding protein. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disordered secretion > [noun] > hormonal disorders hyperthyroidism1900 hypothyroidism1905 hyperpituitarism1909 hypopituitarism1909 hypoparathyroidism1910 thyrotoxicosis1911 hyperparathyroidism1917 hypogonadism1918 Cushing's disease1934 Cushing's syndrome1934 panhypopituitarism1941 pseudohypoparathyroidism1942 Sheehan's syndrome1950 Stein–Leventhal syndrome1950 pseudopseudohypoparathyroidism1952 aldosteronism1954 hyperaldosteronism1955 Albright's dystrophy1957 Albright's hereditary osteodystrophy1962 1942 F. Albright et al. in Endocrinology 30 922 (heading) Pseudo-hypoparathyroidism—an example of ‘Seabright-Bartan Syndrome’. 1966 G. P. Wright & W. S. Symmers Systemic Pathol. II. xxxii. 1126/2 In pseudohypoparathyroidism..the epiphyses and sutures close early, with the result that the patient is short and thickset in stature and has a characteristic round face. 1976 Lancet 20 Nov. 1106/2 Among suggested causes [of neonatal hypocalcaemia] are..decreased responsiveness of end~organs to parathyroid hormone (a form of pseudohypoparathyroidism), and vitamin-D deficiency. 1991 D. J. Weatherall New Genetics & Clin. Pract. (ed. 3) vi. 181 The first disease in which a G protein abnormality was found was a condition called pseudohypoparathyroidism. Derivatives ˌpseudoˌhypoparaˈthyroid adj. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > disordered secretion > [adjective] > hormonal disorders hypothyroid1909 hypoparathyroid1910 hyperthyroid1916 hyperthyroidic1916 hypothyroidic1916 hypopituitary1921 hyperpituitary1924 hypogonadal1933 pseudohypoparathyroid1950 hyperparathyroid1961 1950 Jrnl. Pediatrics 36 567 (title) Pseudohypoparathyroid tetany. 1977 Jrnl. Clin. Endocrinol. & Metabolism 44 420 The resultant changes in renal excretion of adenosine 6':5' monophosphate (cyclic AMP) and inorganic phosphate have been measured in five pseudohypoparathyroid, four hypoparathyroid, and one pseudopseudohypoparathyroid patient. 1992 Biol. Neonate 62 113 Such renal resistance is well known in type 1 pseudohypoparathyroid patients. This entry has been updated (OED Third Edition, September 2007; most recently modified version published online March 2022). < n.1942 |
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