progerian.

Brit.

/prəʊˈdʒɪərɪə/, U.S.

/proʊˈdʒɪriə/

Origin: A borrowing from Greek, combined with an English element. Etymons: Greek προγήρως , -ia suffix¹.

Etymology: < Hellenistic Greek προγήρως prematurely old ( < ancient Greek προ- pro- prefix² + γῆρας old age: see geriatrics n.) + -ia suffix¹.

Medicine.

1. More fully Hutchinson–Gilford progeria, Hutchinson–Gilford progeria syndrome. A rare syndrome affecting children, beginning in the first year of life and characterized by growth retardation and signs usually associated with ageing, such as wrinkling of the skin, alopecia, severe atherosclerosis, and osteoporosis, and typically resulting in death from cardiovascular disease before the age of twenty.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders associated with age > [noun] > progeria

progeria1904

1904 H. Gilford in Practitioner Aug. 210 The name progeria, for which I am indebted to Mr. James Rhoades and Professor Arthur Sidgwick, is not only a far better word [than micromegaly], but is a true description of the distinguishing features of the two cases.

1927 Times (Weekly ed.) 28 Apr. 475/2 Cases of premature senility in children (goblins) described as progeria, the persistence in an adult (ateleioses) of child characters (elves).

1968 Amer. Jrnl. Roentgenol. Radium Ther. Nucl. Med. 103 173 (title) Progeria. Hutchinson-Gilford syndrome.

1987 D. Hall Seasons at Eagle Pond iv. 72 It is not earned and appropriate aging but disease, acid, blight..—mocking the splendor of Autumn as progeria, wretched aging-disease of children, mocks residents of the nursing home.

1993 Mech. Ageing Dev. 70 163 Elastin and type IV collagen production are markedly elevated in fibroblasts derived from the skin of patients with Hutchinson-Gilford progeria.

2003 Jewish Telegr. (Scotl. ed.) 31 Dec. (World Scene) p. v The boys are victims of Huntington–Gilford Progeria syndrome—an extremely rare genetic disease that accelerates the ageing process to about seven times the normal rate.

2. Chiefly with distinguishing word or words: any of several other syndromes characterized by apparent premature ageing in children or adults. Cf. Werner's syndrome at Werner n.

ΘΚΠ

the world > health and disease > ill health > a disease > congenital or hereditary syndromes > [noun]

amyelia1865

amelia1872

congenital myotonia1886

myotonia congenita1887

Thomsen's disease1890

von Recklinghausen's disease1899

pseudoxanthoma1900

Werdnig–Hoffmann1903

myotonia atrophica1908

Fröhlich1909

Milroy's disease1909

Lindau disease1928

Steinert's disease1932

von Hippel–Lindau disease1932

Werner's syndrome1934

Sturge–Weber syndrome1935

gargoylism1936

Morgagni's syndrome1936

Hurler's disease1937

von Willebrand1941

Turner1942

autism1944

hypophosphatasia1948

Klinefelter1950

mucopolysaccharidosis1952

progeria1957

Pendred1960

Down's syndrome1961

Patau's syndrome1961

Marinesco–Sjögren syndrome1962

cri du chat syndrome1964

Prader–Willi syndrome1964

Noonan syndrome1965

Lesch-Nyhan syndrome1966

Wernicke–Korsakoff1966

Down1967

mannosidosis1969

mucolipidosis1970

Asperger's syndrome1971

Angelman syndrome1972

adrenoleukodystrophy1973

SCID1973

severe combined immune deficiency1973

Miller–Dieker syndrome1980

Asperger1988

Asperger's disorder1994

1957 Ulster Med. Jrnl. 26 65 (title) Werner's syndrome (progeria in the adult).

1985 Adv. Exper. Med. Biol. 190 229 (title) A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Gilford progeria syndrome.

1991 Mutat. Res. 256 177 Cells from patients with Werner's syndrome (progeria of the adult), on the other hand, do not suffer from a defect in their antioxidant defence system.

1993 Nature 1 Apr. 411/2 There is speculation that tithonin might reverse the symptoms of Zachary's progeria.

2004 Internat. Jrnl. Biochem. & Cell Biol. 37 947 None of the known progerias represents true precocious ageing.

Derivatives

proˈgerian n. and adj. rare (a) n. a person suffering from progeria; (b) adj. = progeric adj.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders associated with age > [noun] > progeria > person

progerian1913

1913 Lancet 1 Feb. 305/1 Progerians pass from a delayed childhood into a premature old age.

1913 Lancet 1 Feb. 306/1 The total length of the progerian face from nasion to chin is only 84 mm.

1996 Chicago Tribune (Nexis) 14 Aug. 8 There is no medical treatment program for progerians.

proˈgeric adj. of the nature of, affected by, or characteristic of progeria.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders associated with age > [adjective] > progeria

progeric1933

1933 R. W. B. Ellis tr. E. Apert Infantilism vii. 73 (caption) Mould of the upper and lower jaws in the same progeric patient [Fr. le sujet atteint de progeria] as in figs. 11 and 12.

1976 Nature 22 Apr. 713/1 With factor VII-deficient plasma, both normal and progeric cells showed a markedly prolonged clotting time.

1993 Psychiatry Res. 50 93 The metabolic pattern was similar to that seen in normal aging..and is therefore consistent with the classification of myotonic dystrophy as a progeric disease.

proˈgeroid adj. resembling progeria.

ΚΠ

1955 Pediatrics 15 413 (title) Progeroid syndrome: report of a case of pseudo-senilism.

1981 Jrnl. Cell Physiol. 107 255 Myotonic dystrophy..has been suggested to be a segmental progeroid syndrome in man, as this syndrome has some clinical manifestations of premature aging.

1997 Proc. Soc. Exper. Biol. & Med. 215 145 The Ehlers-Danlos progeroid variant offers insight into the function and regulation of the proteoglycan decorin.

This entry has been updated (OED Third Edition, June 2007; most recently modified version published online March 2022).

单词	progeria
释义	progerian. Brit. /prəʊˈdʒɪərɪə/, U.S. /proʊˈdʒɪriə/ Origin: A borrowing from Greek, combined with an English element. Etymons: Greek προγήρως , -ia suffix¹. Etymology: < Hellenistic Greek προγήρως prematurely old ( < ancient Greek προ- pro- prefix² + γῆρας old age: see geriatrics n.) + -ia suffix¹. Medicine. 1. More fully Hutchinson–Gilford progeria, Hutchinson–Gilford progeria syndrome. A rare syndrome affecting children, beginning in the first year of life and characterized by growth retardation and signs usually associated with ageing, such as wrinkling of the skin, alopecia, severe atherosclerosis, and osteoporosis, and typically resulting in death from cardiovascular disease before the age of twenty. ΘΚΠ the world > health and disease > ill health > a disease > disorders associated with age > [noun] > progeria progeria1904 1904 H. Gilford in Practitioner Aug. 210 The name progeria, for which I am indebted to Mr. James Rhoades and Professor Arthur Sidgwick, is not only a far better word [than micromegaly], but is a true description of the distinguishing features of the two cases. 1927 Times (Weekly ed.) 28 Apr. 475/2 Cases of premature senility in children (goblins) described as progeria, the persistence in an adult (ateleioses) of child characters (elves). 1968 Amer. Jrnl. Roentgenol. Radium Ther. Nucl. Med. 103 173 (title) Progeria. Hutchinson-Gilford syndrome. 1987 D. Hall Seasons at Eagle Pond iv. 72 It is not earned and appropriate aging but disease, acid, blight..—mocking the splendor of Autumn as progeria, wretched aging-disease of children, mocks residents of the nursing home. 1993 Mech. Ageing Dev. 70 163 Elastin and type IV collagen production are markedly elevated in fibroblasts derived from the skin of patients with Hutchinson-Gilford progeria. 2003 Jewish Telegr. (Scotl. ed.) 31 Dec. (World Scene) p. v The boys are victims of Huntington–Gilford Progeria syndrome—an extremely rare genetic disease that accelerates the ageing process to about seven times the normal rate. 2. Chiefly with distinguishing word or words: any of several other syndromes characterized by apparent premature ageing in children or adults. Cf. Werner's syndrome at Werner n. ΘΚΠ the world > health and disease > ill health > a disease > congenital or hereditary syndromes > [noun] amyelia1865 amelia1872 congenital myotonia1886 myotonia congenita1887 Thomsen's disease1890 von Recklinghausen's disease1899 pseudoxanthoma1900 Werdnig–Hoffmann1903 myotonia atrophica1908 Fröhlich1909 Milroy's disease1909 Lindau disease1928 Steinert's disease1932 von Hippel–Lindau disease1932 Werner's syndrome1934 Sturge–Weber syndrome1935 gargoylism1936 Morgagni's syndrome1936 Hurler's disease1937 von Willebrand1941 Turner1942 autism1944 hypophosphatasia1948 Klinefelter1950 mucopolysaccharidosis1952 progeria1957 Pendred1960 Down's syndrome1961 Patau's syndrome1961 Marinesco–Sjögren syndrome1962 cri du chat syndrome1964 Prader–Willi syndrome1964 Noonan syndrome1965 Lesch-Nyhan syndrome1966 Wernicke–Korsakoff1966 Down1967 mannosidosis1969 mucolipidosis1970 Asperger's syndrome1971 Angelman syndrome1972 adrenoleukodystrophy1973 SCID1973 severe combined immune deficiency1973 Miller–Dieker syndrome1980 Asperger1988 Asperger's disorder1994 1957 Ulster Med. Jrnl. 26 65 (title) Werner's syndrome (progeria in the adult). 1985 Adv. Exper. Med. Biol. 190 229 (title) A comparison of adult and childhood progerias: Werner syndrome and Hutchinson-Gilford progeria syndrome. 1991 Mutat. Res. 256 177 Cells from patients with Werner's syndrome (progeria of the adult), on the other hand, do not suffer from a defect in their antioxidant defence system. 1993 Nature 1 Apr. 411/2 There is speculation that tithonin might reverse the symptoms of Zachary's progeria. 2004 Internat. Jrnl. Biochem. & Cell Biol. 37 947 None of the known progerias represents true precocious ageing. Derivatives proˈgerian n. and adj. rare (a) n. a person suffering from progeria; (b) adj. = progeric adj. ΘΚΠ the world > health and disease > ill health > a disease > disorders associated with age > [noun] > progeria > person progerian1913 1913 Lancet 1 Feb. 305/1 Progerians pass from a delayed childhood into a premature old age. 1913 Lancet 1 Feb. 306/1 The total length of the progerian face from nasion to chin is only 84 mm. 1996 Chicago Tribune (Nexis) 14 Aug. 8 There is no medical treatment program for progerians. proˈgeric adj. of the nature of, affected by, or characteristic of progeria. ΘΚΠ the world > health and disease > ill health > a disease > disorders associated with age > [adjective] > progeria progeric1933 1933 R. W. B. Ellis tr. E. Apert Infantilism vii. 73 (caption) Mould of the upper and lower jaws in the same progeric patient [Fr. le sujet atteint de progeria] as in figs. 11 and 12. 1976 Nature 22 Apr. 713/1 With factor VII-deficient plasma, both normal and progeric cells showed a markedly prolonged clotting time. 1993 Psychiatry Res. 50 93 The metabolic pattern was similar to that seen in normal aging..and is therefore consistent with the classification of myotonic dystrophy as a progeric disease. proˈgeroid adj. resembling progeria. ΚΠ 1955 Pediatrics 15 413 (title) Progeroid syndrome: report of a case of pseudo-senilism. 1981 Jrnl. Cell Physiol. 107 255 Myotonic dystrophy..has been suggested to be a segmental progeroid syndrome in man, as this syndrome has some clinical manifestations of premature aging. 1997 Proc. Soc. Exper. Biol. & Med. 215 145 The Ehlers-Danlos progeroid variant offers insight into the function and regulation of the proteoglycan decorin. This entry has been updated (OED Third Edition, June 2007; most recently modified version published online March 2022). < n.1904
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