procoagulantn.adj.
/ˌprəʊkəʊˈaɡjᵿlənt/, /ˌprəʊkəʊˈaɡjᵿln̩t/, U.S. /ˌproʊkoʊˈæɡjəl(ə)nt/ Physiology.
A. n.
Any substance that promotes blood clotting, esp. by promoting the conversion of the inactive prothrombin to the clotting enzyme thrombin.
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the world > life > the body > vascular system > blood > components of blood > [noun] > procoagulant
procoagulant1954
1954 Biochimica et Biophysica Acta 14 152 This would be very unlikely if the activation of thromboplastin with calcium were due to the presence of some other procoagulant.
1971 R. S. Shepard Human Physiol. xiv. 243/2 (caption) Intermediates of prothrombin activation may result in the formation of a number of other procoagulants as well as anticoagulants.
2004 Biomed. Materials (Nexis) 1 Apr. 9 The bandage contains a procoagulant, a biological glue-like substance that stimulates the body's own clotting capacity to control active bleeding.
B. adj.
That promotes the coagulation of blood; relating to or of the nature of a procoagulant.
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the world > life > the body > vascular system > blood > components of blood > [adjective] > procoagulant
procoagulant1962
1962 W. H. Seegers Prothrombin ix. 202 There is a procoagulant effect noticeable in whole blood or plasma following the alimentary intake of certain kinds of fats.
1976 Nature 22 Apr. 711/2 It has been shown that human fibroblasts contain a potent procoagulant activity called ‘tissue factor’ (TF).
1993 Brit. Jrnl. Surg. 80 175/1 When injured, the endothelium may become procoagulant, promoting platelet adhesion and activating the coagulation cascade.
This entry has been updated (OED Third Edition, June 2007; most recently modified version published online March 2022).
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n.adj.1954