primidonen.

Brit.

/ˈprɪmᵻdəʊn/, U.S.

/ˈprɪməˌdoʊn/

Origin: Formed within English, by derivation. Etymons: pyrimidine n., -one suffix.

Etymology: < p- + -rimid- (in pyrimidine n.) + -one suffix.

Pharmacology.

An anticonvulsant drug chemically related (and partially metabolized) to phenobarbital, used in the treatment of epilepsy and essential (idiopathic) tremor.Chemical name: 5-ethyl-5-phenylhexahydropyrimidine-4,6-dione; C₁₂H₁₄N₂O₂.A proprietary name for this drug is Mysoline n.

ΘΚΠ

the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > antispasmodic or anticonvulsant > specific substances or preparations

Dilantin1938

phenytoin1942

Artane1948

Mysoline1949

mephenesin1952

troxidone1952

primidone1953

acetazolamide1954

orphenadrine1957

tetrabenazine1958

ethosuximide1960

methsuximide1965

clonazepam1970

valproic1972

valproate1974

1953 Brit. Med. Jrnl. 5 Sept. 540/1 The introduction of primidone (‘mysoline’; 5-phenyl-5-ethylhexahydropyrimidine-4:6-dione) as an anticonvulsant drug some two years ago.

1958 J. H. Burns Lect. Notes Pharmacol. (ed. 5) 52 Primidone (Mysoline) is the most effective agent for the form of epilepsy known as ‘grand mal’.

1986 Neurology 36 121 Primidone, 50 to 1,000 mg/d, reduced the amplitude of essential tremor in both untreated and propranolol-treated patients.

2005 Epilepsy & Behav. 6 260/2 Older drugs like phenobarbital (PB) and especially primidone (PMD)..may be useful [in the treatment of progressive myoclonic epilepsy].

This entry has been updated (OED Third Edition, June 2007; most recently modified version published online March 2022).

单词	primidone
释义	primidonen. Brit. /ˈprɪmᵻdəʊn/, U.S. /ˈprɪməˌdoʊn/ Origin: Formed within English, by derivation. Etymons: pyrimidine n., -one suffix. Etymology: < p- + -rimid- (in pyrimidine n.) + -one suffix. Pharmacology. An anticonvulsant drug chemically related (and partially metabolized) to phenobarbital, used in the treatment of epilepsy and essential (idiopathic) tremor.Chemical name: 5-ethyl-5-phenylhexahydropyrimidine-4,6-dione; C₁₂H₁₄N₂O₂.A proprietary name for this drug is Mysoline n. ΘΚΠ the world > health and disease > healing > medicines or physic > medicines for specific purpose > sedatives, antispasmodics, etc. > [noun] > antispasmodic or anticonvulsant > specific substances or preparations Dilantin1938 phenytoin1942 Artane1948 Mysoline1949 mephenesin1952 troxidone1952 primidone1953 acetazolamide1954 orphenadrine1957 tetrabenazine1958 ethosuximide1960 methsuximide1965 clonazepam1970 valproic1972 valproate1974 1953 Brit. Med. Jrnl. 5 Sept. 540/1 The introduction of primidone (‘mysoline’; 5-phenyl-5-ethylhexahydropyrimidine-4:6-dione) as an anticonvulsant drug some two years ago. 1958 J. H. Burns Lect. Notes Pharmacol. (ed. 5) 52 Primidone (Mysoline) is the most effective agent for the form of epilepsy known as ‘grand mal’. 1986 Neurology 36 121 Primidone, 50 to 1,000 mg/d, reduced the amplitude of essential tremor in both untreated and propranolol-treated patients. 2005 Epilepsy & Behav. 6 260/2 Older drugs like phenobarbital (PB) and especially primidone (PMD)..may be useful [in the treatment of progressive myoclonic epilepsy]. This entry has been updated (OED Third Edition, June 2007; most recently modified version published online March 2022). < n.1953
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