picrotoxinn.

Brit.

/ˌpɪkrəʊˈtɒksɪn/, U.S.

/ˌpɪkroʊˈtɑks(ə)n/

Forms: 1800s– picrotoxin, 1800s– picrotoxine.

Origin: A borrowing from French. Etymon: French picrotoxine.

Etymology: < French picrotoxine (P. F. G. Boullay 1812, in Bull. de pharm. 4 31; < picro- picro- comb. form + Hellenistic Greek τοξικόν poison (see toxicum n.) + French -ine -in suffix¹), with remodelling of the ending after -in suffix¹. Compare Italian picrotossina (1880).

Chemistry.

An intensely bitter polycyclic toxin, C₃₀H₃₄O₁₃, obtained from the seeds of the shrub Anamirta cocculus and related plants of the family Menispermaceae, that is a molecular compound of picrotin and picrotoxinin and is used as a respiratory and central nervous system stimulant. Cf. cocculus indicus n.

ΘΚΠ

the world > physical sensation > use of drugs and poison > poison > [noun] > poisons from plants

aconitum?a1450

aconite1569

cocculus indicus1591

female-bane1601

timbo1725

Suriname poison1756

ipoh1779

upas1783

tanghin1788

picrotoxin1815

nicotine1817

strychnine1819

vauqueline1819

brucia1820

brucine1820

picrotoxia1823

strychnia1823

digitalin1824

dulcamara1828

conine1829

bikh1830

nicotia1830

atropine1836

menispermia1837

nicotina1838

solanine1838

strychnina1838

tanghicin1838

urari1838

conia1842

conicine1842

amanitine1847

oenanthin1848

menispermine1849

tetanine1857

hyoscyamine1858

barbasco1860

nicotylia1862

antiarin1863

xylostein1864

oleandrin1866

zebra poison1871

andromedotoxin1883

abrin1884

ouabain1888

strophanthus1888

toxiresin1890

manchineel1891

tuba1898

taxine1907

phytotoxin1909

oenanthotoxin1911

hypoglycin1954

1815 W. Henry Elements Exper. Chem. (ed. 7) II. i. xx. 254 Picrotoxine.

1840 Penny Cycl. XVIII. 147/1 Picrotoxin..is intensely bitter.

1878 tr. H. W. von Ziemssen et al. Cycl. Pract. Med. XVII. 813 The first and most important step in the treatment of picrotoxin-poisoning.

1969 Science 10 Jan. 146/2 Animals injected after a trial with strychnine or picrotoxine.

1974 V. B. Mountcastle et al. Med. Physiol. (ed. 13) I. vi. 201/2 Strychnine is known to depress postsynaptic but not presynaptic inhibition, while picrotoxin, another convulsive drug, has the reverse effect.

1996 H. M. T. Barros & K. A. Miczek in D. M. Stoff & R. B. Cairns Aggression & Violence xii. 250 The administration of picrotoxin, a GABA antagonist, into the midbrain periaqueductal gray area does not affect the offensive behaviors towards an intruder.

This entry has been updated (OED Third Edition, March 2006; most recently modified version published online March 2022).

单词	picrotoxin
释义	picrotoxinn. Brit. /ˌpɪkrəʊˈtɒksɪn/, U.S. /ˌpɪkroʊˈtɑks(ə)n/ Forms: 1800s– picrotoxin, 1800s– picrotoxine. Origin: A borrowing from French. Etymon: French picrotoxine. Etymology: < French picrotoxine (P. F. G. Boullay 1812, in Bull. de pharm. 4 31; < picro- picro- comb. form + Hellenistic Greek τοξικόν poison (see toxicum n.) + French -ine -in suffix¹), with remodelling of the ending after -in suffix¹. Compare Italian picrotossina (1880). Chemistry. An intensely bitter polycyclic toxin, C₃₀H₃₄O₁₃, obtained from the seeds of the shrub Anamirta cocculus and related plants of the family Menispermaceae, that is a molecular compound of picrotin and picrotoxinin and is used as a respiratory and central nervous system stimulant. Cf. cocculus indicus n. ΘΚΠ the world > physical sensation > use of drugs and poison > poison > [noun] > poisons from plants aconitum?a1450 aconite1569 cocculus indicus1591 female-bane1601 timbo1725 Suriname poison1756 ipoh1779 upas1783 tanghin1788 picrotoxin1815 nicotine1817 strychnine1819 vauqueline1819 brucia1820 brucine1820 picrotoxia1823 strychnia1823 digitalin1824 dulcamara1828 conine1829 bikh1830 nicotia1830 atropine1836 menispermia1837 nicotina1838 solanine1838 strychnina1838 tanghicin1838 urari1838 conia1842 conicine1842 amanitine1847 oenanthin1848 menispermine1849 tetanine1857 hyoscyamine1858 barbasco1860 nicotylia1862 antiarin1863 xylostein1864 oleandrin1866 zebra poison1871 andromedotoxin1883 abrin1884 ouabain1888 strophanthus1888 toxiresin1890 manchineel1891 tuba1898 taxine1907 phytotoxin1909 oenanthotoxin1911 hypoglycin1954 1815 W. Henry Elements Exper. Chem. (ed. 7) II. i. xx. 254 Picrotoxine. 1840 Penny Cycl. XVIII. 147/1 Picrotoxin..is intensely bitter. 1878 tr. H. W. von Ziemssen et al. Cycl. Pract. Med. XVII. 813 The first and most important step in the treatment of picrotoxin-poisoning. 1969 Science 10 Jan. 146/2 Animals injected after a trial with strychnine or picrotoxine. 1974 V. B. Mountcastle et al. Med. Physiol. (ed. 13) I. vi. 201/2 Strychnine is known to depress postsynaptic but not presynaptic inhibition, while picrotoxin, another convulsive drug, has the reverse effect. 1996 H. M. T. Barros & K. A. Miczek in D. M. Stoff & R. B. Cairns Aggression & Violence xii. 250 The administration of picrotoxin, a GABA antagonist, into the midbrain periaqueductal gray area does not affect the offensive behaviors towards an intruder. This entry has been updated (OED Third Edition, March 2006; most recently modified version published online March 2022). < n.1815
随便看	traverser traversers traverses traverses of state traverses of war traversescale traversest traversewarp machine traverseways traversewise traversible traversing traversing jury traversings traversion traversière traverso travertine travertine marble travertine stone trafficstopping trag traga tragacanth tragacanth gum