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单词 phorbol ester
释义

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phorbol ester
A crystalline tetracyclic alcohol, C20H28O6, present (in the form of strongly co-carcinogenic esters) in croton oil; (also) any of these esters. Frequently attributive, esp. in phorbol ester.
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the world > matter > chemistry > organic chemistry > substances from oils and fats > [noun]
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phorbol1935
1935 Chem. Abstr. 29 2533 Phorbol (C20H28O6 or C20H30O6) with very dilute H2SO4 in N2 gives 38% crotophorbolon.
1939 Thorpe's Dict. Appl. Chem. (ed. 4) III. 434/2 Phorbol and the product of its benzoylation are physiologically inactive, but the (? tetra-)acetate is highly toxic.
1967 Naturwissenschaften 54 284/1 Phorbol esters show a true tumor promoting quality without accompanying tumorigenic activity provided the doses applied are small enough.
1994 Sci. Amer. June 64/2 The chemical [sc. prostratin]..was not being studied as a drug, because it was a phorbol, a class of chemicals that promotes the development of tumors.
2004 Tissue & Cell 36 149 Long-term exposure to the tumor promoter phorbol myristate acetate..affects Sertoli cell morphology, as well as actin and vinculin organization in vitro.
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