pharmacophoren.
/ˈfɑːməkəˌfɔː/, U.S. /ˈfɑrməkəˌfɔr/ Pharmacology.
The part of a molecule that is responsible for its characteristic pharmacological activity; a pharmacologically active group.
ΚΠ
1964 Biochem. Pharmacol. 13 332 The second is a specific structural requirement for which we will use the term ‘pharmacophore’.
1971 L. B. Kier Molecular Orbital Theory in Drug Res. viii. 170 The molecule is permitted to assume a pattern identical to that previously calculated for the muscarinic pharmacophore.
1977 Jrnl. Medicinal Chem. 20 85 Attempts to elucidate the prolactin release inhibiting pharmacophore within the ergoline structure.
1994 Chem. in Brit. Oct. 809/2 Drug design strategy..generates possible pharmacophores based on a set of biologically active compounds.
2000 Denver Post 10 Sept. l27 (advt.) A dynamic drug discovery company applying the latest innovations..for identification and characterization of pharmacophores from natural products.
This is a new entry (OED Third Edition, December 2002; most recently modified version published online March 2022).
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n.1964