phenylketonuricn.adj.

Brit.

/ˌfiːnʌɪlˌkiːtəˈnjʊərɪk/,

/ˌfɛnʌɪlˌkiːtəˈnjʊərɪk/, U.S.

/ˈˌfɛnəlˌkitnˈ(j)ʊrɪk/,

/ˈˌfinəlˌkitnˈ(j)ʊrɪk/; see also phenyl n.

Origin: Formed within English, by derivation. Etymons: phenylketonuria n., -ic suffix.

Etymology: < phenylketonuria n. + -ic suffix.

Medicine.

A. n.

A person affected with phenylketonuria, or who has an inherited enzyme abnormality that results in phenylketonuria.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > metabolic disorders > [noun] > other metabolic disorders > person

phenylketonuric1937

1937 Biochem. Jrnl. 31 270 Experiments were carried out..to determine the effects of feeding phenylalanine to a phenylketonuric on a low protein diet.

1975 Nature 4 Dec. 462/3 Even if an observed difference is genetic it does not mean that a trait cannot be altered substantially by an appropriate environmental change. An example is the treatment of phenylketonurics.

1988 L. Stryer Biochem. (ed. 3) xxi. 513 Some minor fates of phenylalanine in normal persons become prominent in phenylketonurics.

B. adj.

Affected with phenylketonuria; of or relating to phenylketonuria.

ΘΚΠ

the world > health and disease > ill health > a disease > disorders of internal organs > metabolic disorders > [adjective] > other metabolic disorders

von Gierke1933

ketotic1943

cystinotic1961

orotic aciduric1961

phenylketonuric1961

1961 Lancet 26 Aug. 465/2 This suggests that there is no biochemical reason why any phenylketonuric woman should not have normal children.

1969 Jrnl. Pediatrics 74 924/1 The high incidence of mental retardation among heterozygote offspring of phenylketonuric mothers offers one of the most convincing arguments in favor of the hypothesis that phenylalanine or one of its metabolites damages the developing nervous system.

1999 Proc. National Acad. Sci. U.S.A. 96 3160 (title) A model of human phenylalanine metabolism in normal subjects and in phenylketonuric patients.

This entry has been updated (OED Third Edition, December 2005; most recently modified version published online March 2022).

单词	phenylketonuric
释义	phenylketonuricn.adj. Brit. /ˌfiːnʌɪlˌkiːtəˈnjʊərɪk/, /ˌfɛnʌɪlˌkiːtəˈnjʊərɪk/, U.S. /ˈˌfɛnəlˌkitnˈ(j)ʊrɪk/, /ˈˌfinəlˌkitnˈ(j)ʊrɪk/; see also phenyl n. Origin: Formed within English, by derivation. Etymons: phenylketonuria n., -ic suffix. Etymology: < phenylketonuria n. + -ic suffix. Medicine. A. n. A person affected with phenylketonuria, or who has an inherited enzyme abnormality that results in phenylketonuria. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > metabolic disorders > [noun] > other metabolic disorders > person phenylketonuric1937 1937 Biochem. Jrnl. 31 270 Experiments were carried out..to determine the effects of feeding phenylalanine to a phenylketonuric on a low protein diet. 1975 Nature 4 Dec. 462/3 Even if an observed difference is genetic it does not mean that a trait cannot be altered substantially by an appropriate environmental change. An example is the treatment of phenylketonurics. 1988 L. Stryer Biochem. (ed. 3) xxi. 513 Some minor fates of phenylalanine in normal persons become prominent in phenylketonurics. B. adj. Affected with phenylketonuria; of or relating to phenylketonuria. ΘΚΠ the world > health and disease > ill health > a disease > disorders of internal organs > metabolic disorders > [adjective] > other metabolic disorders von Gierke1933 ketotic1943 cystinotic1961 orotic aciduric1961 phenylketonuric1961 1961 Lancet 26 Aug. 465/2 This suggests that there is no biochemical reason why any phenylketonuric woman should not have normal children. 1969 Jrnl. Pediatrics 74 924/1 The high incidence of mental retardation among heterozygote offspring of phenylketonuric mothers offers one of the most convincing arguments in favor of the hypothesis that phenylalanine or one of its metabolites damages the developing nervous system. 1999 Proc. National Acad. Sci. U.S.A. 96 3160 (title) A model of human phenylalanine metabolism in normal subjects and in phenylketonuric patients. This entry has been updated (OED Third Edition, December 2005; most recently modified version published online March 2022). < n.adj.1937
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