perforinn.
/ˈpəːf(ə)rɪn/, U.S. /ˈpərfərɪn/ Biochemistry.
A protein released by killer cells of the immune system which destroys targeted cells by creating pore-like lesions in their membranes.
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the world > life > biology > substance > proteins > [noun]
casein1838
albuminoid1855
xanthoglobulin1868
myochrome1872
xanthoprotein1883
histone1885
globulose1886
phaseolin1893
leucosin1894
nucleohistone1894
nucleon1895
mucoid1898
protone1898
mucinoid1902
myohaemoglobin1906
nucleoprotamine1911
cytozyme1914
leaf protein1917
cytochrome1925
mucoprotein1925
myoglobin1925
flavoprotein1934
oxymyoglobin1935
ferritin1937
lipovitellin1942
arthropodin1947
trypticase1947
erythropoietin1948
phosvitin1948
opsin1951
orosomucoid1955
metallothionein1960
plastocyanin1961
aequorin1962
ferredoxin1962
LDL1962
fetoprotein1964
thioredoxin1964
actinin1965
adrenodoxin1965
lactoferrin1965
myoglobulin1965
rubredoxin1965
uniporter1967
miraculin1968
nexin1970
bacteriorhodopsin1971
molybdoprotein1971
monellin1972
cytokine1974
ankyrin1975
clathrin1975
electromorph1975
tau1975
uniport1975
microtrabecula1976
porin1976
osteocalcin1977
calmodulin1978
monokine1978
PCNA1978
vimentin1978
interleukin1979
laminin1979
titin1979
villin1979
cyclin1981
triskele1981
acumentin1982
perforin1983
statin1985
activin1986
addressin1988
synuclein1988
chemokine1992
1983 G. Dennert & E. R. Podack in Federation Proc. (Federation Amer. Soc. Exper. Biol.) 42 561/1 Analysis of membrane fragments by negative staining revealed the formation of two types of membrane lesions (poly perforins).
1989 Nature 9 Mar. 183/3 Integrating the..molecular homologies (C1q with collagen; the serine proteases; the perforins with terminal attack-proteins..) with the consequences for pathological processes.
2002 Glasgow Herald (Nexis) 7 Oct. 4 They also produced higher levels of a molecule called perforin, which helps them destroy cells invaded by the virus.
This entry has been updated (OED Third Edition, December 2005; most recently modified version published online March 2022).
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n.1983